Mild Cognitive Impairment Staging Yields Genetic Susceptibility, Biomarker, and Neuroimaging Differences

Mild Cognitive Impairment Staging Yields Genetic Susceptibility, Biomarker, and Neuroimaging Differences

IntroductionWhile Alzheimer’s disease (AD) is divided into severity stages, mild cognitive impairment (MCI) remains a solitary construct despite clinical and prognostic heterogeneity. This study aimed to characterize differences in genetic, cerebrospinal fluid (CSF), neuroimaging, and neuropsycholog...

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Main Authors: Elizabeth E. Moore, Dandan Liu, Kimberly R. Pechman, Lealani Mae Y. Acosta, Susan P. Bell, L. Taylor Davis, Kaj Blennow, Henrik Zetterberg, Bennett A. Landman, Matthew S. Schrag, Timothy J. Hohman, Katherine A. Gifford, Angela L. Jefferson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
mild cognitive impairment
clinical staging
cerebrospinal fluid
apolipoprotein E
brain MRI
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00139/full

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