Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence

The aim of this study was to review emerging evidence of novel treatments for anxiety disorders. We searched PubMed and EMBASE for evidence-based therapeutic alternatives for anxiety disorders in adults, covering the past five years. Eligible articles were systematic reviews (with or without meta-an...

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Main Authors: Vitor Iglesias Mangolini, Laura Helena Andrade, Francisco Lotufo-Neto, Yuan-Pang Wang
Format: Article
Language:English
Published: Elsevier España 2019-11-01
Series:Clinics
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100316&tlng=en
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author Vitor Iglesias Mangolini
Laura Helena Andrade
Francisco Lotufo-Neto
Yuan-Pang Wang
author_facet Vitor Iglesias Mangolini
Laura Helena Andrade
Francisco Lotufo-Neto
Yuan-Pang Wang
author_sort Vitor Iglesias Mangolini
collection DOAJ
description The aim of this study was to review emerging evidence of novel treatments for anxiety disorders. We searched PubMed and EMBASE for evidence-based therapeutic alternatives for anxiety disorders in adults, covering the past five years. Eligible articles were systematic reviews (with or without meta-analysis), which evaluated treatment effectiveness of either nonbiological or biological interventions for anxiety disorders. Retrieved articles were summarized as an overview. We assessed methods, quality of evidence, and risk of bias of the articles. Nineteen systematic reviews provided information on almost 88 thousand participants, distributed across 811 clinical trials. Regarding the interventions, 11 reviews investigated psychological or nonbiological treatments; 5, pharmacological or biological; and 3, more than one type of active intervention. Computer-delivered psychological interventions were helpful for treating anxiety of low-to-moderate intensity, but the therapist-oriented approaches had greater results. Recommendations for regular exercise, mindfulness, yoga, and safety behaviors were applicable to anxiety. Transcranial magnetic stimulation, medication augmentation, and new pharmacological agents (vortioxetine) presented inconclusive benefits in patients with anxiety disorders who presented partial responses or refractoriness to standard treatment. New treatment options for anxiety disorders should only be provided to the community after a thorough examination of their efficacy.
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spelling doaj.art-f80617375b7445fcb8e93e0c1bff45802022-12-22T02:47:14ZengElsevier EspañaClinics1980-53222019-11-017410.6061/clinics/2019/e1316Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidenceVitor Iglesias Mangolinihttps://orcid.org/0000-0002-5958-7622Laura Helena Andradehttps://orcid.org/0000-0002-2362-3521Francisco Lotufo-Netohttps://orcid.org/0000-0002-2043-7643Yuan-Pang Wanghttps://orcid.org/0000-0001-7076-8312The aim of this study was to review emerging evidence of novel treatments for anxiety disorders. We searched PubMed and EMBASE for evidence-based therapeutic alternatives for anxiety disorders in adults, covering the past five years. Eligible articles were systematic reviews (with or without meta-analysis), which evaluated treatment effectiveness of either nonbiological or biological interventions for anxiety disorders. Retrieved articles were summarized as an overview. We assessed methods, quality of evidence, and risk of bias of the articles. Nineteen systematic reviews provided information on almost 88 thousand participants, distributed across 811 clinical trials. Regarding the interventions, 11 reviews investigated psychological or nonbiological treatments; 5, pharmacological or biological; and 3, more than one type of active intervention. Computer-delivered psychological interventions were helpful for treating anxiety of low-to-moderate intensity, but the therapist-oriented approaches had greater results. Recommendations for regular exercise, mindfulness, yoga, and safety behaviors were applicable to anxiety. Transcranial magnetic stimulation, medication augmentation, and new pharmacological agents (vortioxetine) presented inconclusive benefits in patients with anxiety disorders who presented partial responses or refractoriness to standard treatment. New treatment options for anxiety disorders should only be provided to the community after a thorough examination of their efficacy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100316&tlng=enAnxiety DisordersTherapeuticsPsychotherapyPsychopharmacologySystematic Review
spellingShingle Vitor Iglesias Mangolini
Laura Helena Andrade
Francisco Lotufo-Neto
Yuan-Pang Wang
Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence
Clinics
Anxiety Disorders
Therapeutics
Psychotherapy
Psychopharmacology
Systematic Review
title Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence
title_full Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence
title_fullStr Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence
title_full_unstemmed Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence
title_short Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence
title_sort treatment of anxiety disorders in clinical practice a critical overview of recent systematic evidence
topic Anxiety Disorders
Therapeutics
Psychotherapy
Psychopharmacology
Systematic Review
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100316&tlng=en
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