What Is the Comparative Efficacy of Surgical, Endoscopic, Transanal Resection, and Radiotherapy Modalities in the Treatment of Rectal Cancer?
Background: Rectal cancer is a significant healthcare burden, and effective treatment is crucial. This research aims to compare the effectiveness of surgical and endoscopic resection, transanal resection, and radiotherapy. Methods: A literature analysis was conducted in order to identify relevant st...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/16/2347 |
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| author | Alexandru Isaic Alexandru Cătălin Motofelea Dan Costachescu Gheorghe Nicusor Pop Bogdan Totolici Dorel Popovici Razvan Gheorghe Diaconescu |
| author_facet | Alexandru Isaic Alexandru Cătălin Motofelea Dan Costachescu Gheorghe Nicusor Pop Bogdan Totolici Dorel Popovici Razvan Gheorghe Diaconescu |
| author_sort | Alexandru Isaic |
| collection | DOAJ |
| description | Background: Rectal cancer is a significant healthcare burden, and effective treatment is crucial. This research aims to compare the effectiveness of surgical and endoscopic resection, transanal resection, and radiotherapy. Methods: A literature analysis was conducted in order to identify relevant studies, by comparing the different surgical approaches and variables affecting treatment decisions. The findings were analyzed and synthesized to provide a comprehensive overview. Results: Surgical treatment, particularly TME (total mesorectal excision), proved consistent efficacy in achieving complete tumor resection and improving long-term survival. Endoscopic treatment and transanal resection techniques were promising for early-stage tumors but were associated with higher local recurrence rates. Radiotherapy, especially in combination with chemotherapy, played a crucial role in locally advanced cases, improving local control and reducing recurrence risk. Patient data, tumor characteristics, and healthcare system factors were identified as important factors in treatment modality selection. Conclusion: Surgical treatment, specifically TME, remains the recommended standard approach for rectal cancer, providing excellent oncological outcomes. Endoscopic treatment and transanal resection techniques can be considered for selected early-stage cases, while radiotherapy is beneficial for locally advanced tumors. Treatment decisions should be personalized based on patient and tumor characteristics, considering the available resources and expertise within the healthcare system. |
| first_indexed | 2024-03-10T23:54:53Z |
| format | Article |
| id | doaj.art-f806193b88594332a58774e0e836d986 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-10T23:54:53Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-f806193b88594332a58774e0e836d9862023-11-19T01:19:43ZengMDPI AGHealthcare2227-90322023-08-011116234710.3390/healthcare11162347What Is the Comparative Efficacy of Surgical, Endoscopic, Transanal Resection, and Radiotherapy Modalities in the Treatment of Rectal Cancer?Alexandru Isaic0Alexandru Cătălin Motofelea1Dan Costachescu2Gheorghe Nicusor Pop3Bogdan Totolici4Dorel Popovici5Razvan Gheorghe Diaconescu6IInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, RomaniaDepartment of Internal Medicine, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Orthopedics-Traumatology, Urology, Radiology, and Medical Imaging, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaCenter for Modeling Biological Systems and Data Analysis, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania1st Clinic of General Surgery, Arad County Emergency Clinical Hospital, 310158 Arad, RomaniaDepartment of Oncology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaOncoHelp Hospital, 300239 Timisoara, RomaniaBackground: Rectal cancer is a significant healthcare burden, and effective treatment is crucial. This research aims to compare the effectiveness of surgical and endoscopic resection, transanal resection, and radiotherapy. Methods: A literature analysis was conducted in order to identify relevant studies, by comparing the different surgical approaches and variables affecting treatment decisions. The findings were analyzed and synthesized to provide a comprehensive overview. Results: Surgical treatment, particularly TME (total mesorectal excision), proved consistent efficacy in achieving complete tumor resection and improving long-term survival. Endoscopic treatment and transanal resection techniques were promising for early-stage tumors but were associated with higher local recurrence rates. Radiotherapy, especially in combination with chemotherapy, played a crucial role in locally advanced cases, improving local control and reducing recurrence risk. Patient data, tumor characteristics, and healthcare system factors were identified as important factors in treatment modality selection. Conclusion: Surgical treatment, specifically TME, remains the recommended standard approach for rectal cancer, providing excellent oncological outcomes. Endoscopic treatment and transanal resection techniques can be considered for selected early-stage cases, while radiotherapy is beneficial for locally advanced tumors. Treatment decisions should be personalized based on patient and tumor characteristics, considering the available resources and expertise within the healthcare system.https://www.mdpi.com/2227-9032/11/16/2347TMETaTMETEMradiotherapy |
| spellingShingle | Alexandru Isaic Alexandru Cătălin Motofelea Dan Costachescu Gheorghe Nicusor Pop Bogdan Totolici Dorel Popovici Razvan Gheorghe Diaconescu What Is the Comparative Efficacy of Surgical, Endoscopic, Transanal Resection, and Radiotherapy Modalities in the Treatment of Rectal Cancer? Healthcare TME TaTME TEM radiotherapy |
| title | What Is the Comparative Efficacy of Surgical, Endoscopic, Transanal Resection, and Radiotherapy Modalities in the Treatment of Rectal Cancer? |
| title_full | What Is the Comparative Efficacy of Surgical, Endoscopic, Transanal Resection, and Radiotherapy Modalities in the Treatment of Rectal Cancer? |
| title_fullStr | What Is the Comparative Efficacy of Surgical, Endoscopic, Transanal Resection, and Radiotherapy Modalities in the Treatment of Rectal Cancer? |
| title_full_unstemmed | What Is the Comparative Efficacy of Surgical, Endoscopic, Transanal Resection, and Radiotherapy Modalities in the Treatment of Rectal Cancer? |
| title_short | What Is the Comparative Efficacy of Surgical, Endoscopic, Transanal Resection, and Radiotherapy Modalities in the Treatment of Rectal Cancer? |
| title_sort | what is the comparative efficacy of surgical endoscopic transanal resection and radiotherapy modalities in the treatment of rectal cancer |
| topic | TME TaTME TEM radiotherapy |
| url | https://www.mdpi.com/2227-9032/11/16/2347 |
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