The New Era of Biologics in Atopic Dermatitis: A Review
Atopic dermatitis (AD) is a prevalent inflammatory skin disorder affecting all ages and ethnic groups. The age-dependent varying appearance and extent of pruritic lesions are accompanied by distinct individual suffering, highlighting the importance of effective treatment options. Over the past years...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Mattioli1885
2021-10-01
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| Series: | Dermatology Practical & Conceptual |
| Subjects: | |
| Online Access: | https://dpcj.org/index.php/dpc/article/view/2120 |
| _version_ | 1828122697882664960 |
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| author | Simon Schneider Linda Li Alexander Zink |
| author_facet | Simon Schneider Linda Li Alexander Zink |
| author_sort | Simon Schneider |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a prevalent inflammatory skin disorder affecting all ages and ethnic groups. The age-dependent varying appearance and extent of pruritic lesions are accompanied by distinct individual suffering, highlighting the importance of effective treatment options. Over the past years, systemic drugs have considerably extended therapeutic approaches of patients with moderate to severe AD, in particular, new biologics, most notably dupilumab has appeared as major breakthrough. In addition to monoclonal blockade of IL-4 and IL-13 pathway, more cytokines have been found to play a substantial role in AD pathogenesis, presenting potential targets for new therapy options. |
| first_indexed | 2024-04-11T14:41:14Z |
| format | Article |
| id | doaj.art-f807247e38bb471c8cfb27ac121f3b51 |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-04-11T14:41:14Z |
| publishDate | 2021-10-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-f807247e38bb471c8cfb27ac121f3b512022-12-22T04:18:01ZengMattioli1885Dermatology Practical & Conceptual2160-93812021-10-0110.5826/dpc.1104a144The New Era of Biologics in Atopic Dermatitis: A ReviewSimon Schneider0Linda Li1Alexander Zink2Technical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, GermanyTechnical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, GermanyTechnical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, Germany; Division of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, Stockholm, SwedenAtopic dermatitis (AD) is a prevalent inflammatory skin disorder affecting all ages and ethnic groups. The age-dependent varying appearance and extent of pruritic lesions are accompanied by distinct individual suffering, highlighting the importance of effective treatment options. Over the past years, systemic drugs have considerably extended therapeutic approaches of patients with moderate to severe AD, in particular, new biologics, most notably dupilumab has appeared as major breakthrough. In addition to monoclonal blockade of IL-4 and IL-13 pathway, more cytokines have been found to play a substantial role in AD pathogenesis, presenting potential targets for new therapy options.https://dpcj.org/index.php/dpc/article/view/2120atopic dermatitis,therapybiologicaldupilumab |
| spellingShingle | Simon Schneider Linda Li Alexander Zink The New Era of Biologics in Atopic Dermatitis: A Review Dermatology Practical & Conceptual atopic dermatitis, therapy biological dupilumab |
| title | The New Era of Biologics in Atopic Dermatitis: A Review |
| title_full | The New Era of Biologics in Atopic Dermatitis: A Review |
| title_fullStr | The New Era of Biologics in Atopic Dermatitis: A Review |
| title_full_unstemmed | The New Era of Biologics in Atopic Dermatitis: A Review |
| title_short | The New Era of Biologics in Atopic Dermatitis: A Review |
| title_sort | new era of biologics in atopic dermatitis a review |
| topic | atopic dermatitis, therapy biological dupilumab |
| url | https://dpcj.org/index.php/dpc/article/view/2120 |
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