T–cell–based immunotherapy for osteosarcoma: challenges and opportunities
AbstractEven though combining surgery with chemotherapy has significantly improved the prognosis of osteosarcoma patients, advanced, metastatic or recurrent osteosarcomas are often nonresponsive to chemotherapy, making development of novel efficient therapeutic methods an urgent need. Adoptive immun...
| Main Authors: | , , , |
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| פורמט: | Article |
| שפה: | English |
| יצא לאור: |
Frontiers Media S.A.
2016-09-01
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| סדרה: | Frontiers in Immunology |
| נושאים: | |
| גישה מקוונת: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00353/full |
| _version_ | 1828852702584504320 |
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| author | Zhan Wang Binghao Li Yingqing Ren Zhaoming Ye |
| author_facet | Zhan Wang Binghao Li Yingqing Ren Zhaoming Ye |
| author_sort | Zhan Wang |
| collection | DOAJ |
| description | AbstractEven though combining surgery with chemotherapy has significantly improved the prognosis of osteosarcoma patients, advanced, metastatic or recurrent osteosarcomas are often nonresponsive to chemotherapy, making development of novel efficient therapeutic methods an urgent need. Adoptive immunotherapy has the potential to be a useful non-surgical modality for treatment of osteosarcoma. Recently, alternative strategies, including immunotherapies using naturally occurring or genetically modified T cells, have been found to hold promise in the treatment of hematologic malignancies and solid tumors. In this review, we will discuss possible T-cell-based therapies against osteosarcoma with a special emphasis on combination strategies to improve the effectiveness of ATCT (adoptive T cell transfer), and thus to provide a rationale for the clinical development of immunotherapies. |
| first_indexed | 2024-12-12T23:58:55Z |
| format | Article |
| id | doaj.art-f80801dada9247d4b7aa3a6a2edba6e4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T23:58:55Z |
| publishDate | 2016-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f80801dada9247d4b7aa3a6a2edba6e42022-12-22T00:06:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-09-01710.3389/fimmu.2016.00353215217T–cell–based immunotherapy for osteosarcoma: challenges and opportunitiesZhan Wang0Binghao Li1Yingqing Ren2Zhaoming Ye3Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of MedicineDepartment of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of MedicineDepartment of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of MedicineDepartment of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of MedicineAbstractEven though combining surgery with chemotherapy has significantly improved the prognosis of osteosarcoma patients, advanced, metastatic or recurrent osteosarcomas are often nonresponsive to chemotherapy, making development of novel efficient therapeutic methods an urgent need. Adoptive immunotherapy has the potential to be a useful non-surgical modality for treatment of osteosarcoma. Recently, alternative strategies, including immunotherapies using naturally occurring or genetically modified T cells, have been found to hold promise in the treatment of hematologic malignancies and solid tumors. In this review, we will discuss possible T-cell-based therapies against osteosarcoma with a special emphasis on combination strategies to improve the effectiveness of ATCT (adoptive T cell transfer), and thus to provide a rationale for the clinical development of immunotherapies.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00353/fullT cellCombination strategyosteosarcoma(OS)ACT (adoptive cell transfer)tumor microenvironment(TMA) |
| spellingShingle | Zhan Wang Binghao Li Yingqing Ren Zhaoming Ye T–cell–based immunotherapy for osteosarcoma: challenges and opportunities Frontiers in Immunology T cell Combination strategy osteosarcoma(OS) ACT (adoptive cell transfer) tumor microenvironment(TMA) |
| title | T–cell–based immunotherapy for osteosarcoma: challenges and opportunities |
| title_full | T–cell–based immunotherapy for osteosarcoma: challenges and opportunities |
| title_fullStr | T–cell–based immunotherapy for osteosarcoma: challenges and opportunities |
| title_full_unstemmed | T–cell–based immunotherapy for osteosarcoma: challenges and opportunities |
| title_short | T–cell–based immunotherapy for osteosarcoma: challenges and opportunities |
| title_sort | t cell based immunotherapy for osteosarcoma challenges and opportunities |
| topic | T cell Combination strategy osteosarcoma(OS) ACT (adoptive cell transfer) tumor microenvironment(TMA) |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00353/full |
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