T–cell–based immunotherapy for osteosarcoma: challenges and opportunities

T–cell–based immunotherapy for osteosarcoma: challenges and opportunities

AbstractEven though combining surgery with chemotherapy has significantly improved the prognosis of osteosarcoma patients, advanced, metastatic or recurrent osteosarcomas are often nonresponsive to chemotherapy, making development of novel efficient therapeutic methods an urgent need. Adoptive immun...

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Bibliographic Details
Main Authors: Zhan Wang, Binghao Li, Yingqing Ren, Zhaoming Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Immunology
Subjects:
T cell
Combination strategy
osteosarcoma(OS)
ACT (adoptive cell transfer)
tumor microenvironment(TMA)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00353/full

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