1型糖尿病管理的改进空间
Abstract Aims/Hypothesis Optimal diabetes care and risk factor management are important to delay micro‐ and macrovascular complications in individuals with type 1 diabetes (T1D). Ongoing improvement of management strategies requires the evaluation of target achievement and identification of risk fac...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13368 |
| _version_ | 1797861188217864192 |
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| author | Rita D. M. Varkevisser Erwin Birnie Dick Mul Peter R. vanDijk Henk‐Jan Aanstoot Bruce H. R. Wolffenbuttel Melanie M. van derKlauw |
| author_facet | Rita D. M. Varkevisser Erwin Birnie Dick Mul Peter R. vanDijk Henk‐Jan Aanstoot Bruce H. R. Wolffenbuttel Melanie M. van derKlauw |
| author_sort | Rita D. M. Varkevisser |
| collection | DOAJ |
| description | Abstract Aims/Hypothesis Optimal diabetes care and risk factor management are important to delay micro‐ and macrovascular complications in individuals with type 1 diabetes (T1D). Ongoing improvement of management strategies requires the evaluation of target achievement and identification of risk factors in individuals who do (or do not) achieve these targets. Methods Cross‐sectional data were collected from adults with T1D visiting six diabetes centers in the Netherlands in 2018. Targets were defined as glycated hemoglobin (HbA1c) <53 mmol/mol, low‐density lipoprotein‐cholesterol (LDL‐c) <2.6 mmoL/L (no cardiovascular disease [CVD] present) or <1.8 mmoL/L (CVD present), or blood pressure (BP) <140/90 mm Hg. Target achievement was compared for individuals with and without CVD. Results Data from 1737 individuals were included. Mean HbA1c was 63 mmol/mol (7.9%), LDL‐c was 2.67 mmoL/L, and BP 131/76 mm Hg. In individuals with CVD, 24%, 33%, and 46% achieved HbA1c, LDL‐c, and BP targets respectively. In individuals without CVD these percentages were 29%, 54%, and 77%, respectively. Individuals with CVD did not have any significant risk factors for HbA1c, LDL‐c, and BP target achievement. In comparison, individuals without CVD were more likely to achieve glycemic targets if they were men and insulin pump users. Smoking, microvascular complications, and the prescription of lipid‐lowering and antihypertensive medication were negatively associated with glycemic target achievement. No characteristics were associated with LDL‐c target achievement. Microvascular complications and antihypertensive medication prescription were negatively associated with BP target attainment. Conclusion Opportunities for improvement of diabetes management exist for the achievement of glycemic, lipid, and BP targets but may differ between individuals with and without CVD. |
| first_indexed | 2024-04-09T21:59:13Z |
| format | Article |
| id | doaj.art-f80823cf92da4c629d653a58b55bb15c |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-09T21:59:13Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-f80823cf92da4c629d653a58b55bb15c2023-03-24T03:20:06ZengWileyJournal of Diabetes1753-03931753-04072023-03-0115325526310.1111/1753-0407.133681型糖尿病管理的改进空间Rita D. M. Varkevisser0Erwin Birnie1Dick Mul2Peter R. vanDijk3Henk‐Jan Aanstoot4Bruce H. R. Wolffenbuttel5Melanie M. van derKlauw6Department of Endocrinology University of Groningen, University Medical Center Groningen Groningen The NetherlandsDiabeter Nederland, Center for Focussed Diabetes Care and Research Rotterdam The NetherlandsDiabeter Nederland, Center for Focussed Diabetes Care and Research Rotterdam The NetherlandsDepartment of Endocrinology University of Groningen, University Medical Center Groningen Groningen The NetherlandsDiabeter Nederland, Center for Focussed Diabetes Care and Research Rotterdam The NetherlandsDepartment of Endocrinology University of Groningen, University Medical Center Groningen Groningen The NetherlandsDepartment of Endocrinology University of Groningen, University Medical Center Groningen Groningen The NetherlandsAbstract Aims/Hypothesis Optimal diabetes care and risk factor management are important to delay micro‐ and macrovascular complications in individuals with type 1 diabetes (T1D). Ongoing improvement of management strategies requires the evaluation of target achievement and identification of risk factors in individuals who do (or do not) achieve these targets. Methods Cross‐sectional data were collected from adults with T1D visiting six diabetes centers in the Netherlands in 2018. Targets were defined as glycated hemoglobin (HbA1c) <53 mmol/mol, low‐density lipoprotein‐cholesterol (LDL‐c) <2.6 mmoL/L (no cardiovascular disease [CVD] present) or <1.8 mmoL/L (CVD present), or blood pressure (BP) <140/90 mm Hg. Target achievement was compared for individuals with and without CVD. Results Data from 1737 individuals were included. Mean HbA1c was 63 mmol/mol (7.9%), LDL‐c was 2.67 mmoL/L, and BP 131/76 mm Hg. In individuals with CVD, 24%, 33%, and 46% achieved HbA1c, LDL‐c, and BP targets respectively. In individuals without CVD these percentages were 29%, 54%, and 77%, respectively. Individuals with CVD did not have any significant risk factors for HbA1c, LDL‐c, and BP target achievement. In comparison, individuals without CVD were more likely to achieve glycemic targets if they were men and insulin pump users. Smoking, microvascular complications, and the prescription of lipid‐lowering and antihypertensive medication were negatively associated with glycemic target achievement. No characteristics were associated with LDL‐c target achievement. Microvascular complications and antihypertensive medication prescription were negatively associated with BP target attainment. Conclusion Opportunities for improvement of diabetes management exist for the achievement of glycemic, lipid, and BP targets but may differ between individuals with and without CVD.https://doi.org/10.1111/1753-0407.133681型糖尿病心血管疾病血糖血压脂代谢胆固醇 |
| spellingShingle | Rita D. M. Varkevisser Erwin Birnie Dick Mul Peter R. vanDijk Henk‐Jan Aanstoot Bruce H. R. Wolffenbuttel Melanie M. van derKlauw 1型糖尿病管理的改进空间 Journal of Diabetes 1型糖尿病 心血管疾病 血糖 血压 脂代谢 胆固醇 |
| title | 1型糖尿病管理的改进空间 |
| title_full | 1型糖尿病管理的改进空间 |
| title_fullStr | 1型糖尿病管理的改进空间 |
| title_full_unstemmed | 1型糖尿病管理的改进空间 |
| title_short | 1型糖尿病管理的改进空间 |
| title_sort | 1型糖尿病管理的改进空间 |
| topic | 1型糖尿病 心血管疾病 血糖 血压 脂代谢 胆固醇 |
| url | https://doi.org/10.1111/1753-0407.13368 |
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