Non-immune cell components in tumor microenvironment influencing lung cancer Immunotherapy
Lung cancer (LC) is one of the leading causes of cancer-related deaths worldwide, with a significant morbidity and mortality rate, endangering human life and health. The introduction of immunotherapies has significantly altered existing cancer treatment strategies and is expected to improve immune r...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223011277 |
| _version_ | 1797686902397075456 |
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| author | Jingtao Zhang Shuai Liu Xiubao Chen Xiangdong Xu Fei Xu |
| author_facet | Jingtao Zhang Shuai Liu Xiubao Chen Xiangdong Xu Fei Xu |
| author_sort | Jingtao Zhang |
| collection | DOAJ |
| description | Lung cancer (LC) is one of the leading causes of cancer-related deaths worldwide, with a significant morbidity and mortality rate, endangering human life and health. The introduction of immunotherapies has significantly altered existing cancer treatment strategies and is expected to improve immune responses, objective response rates, and survival rates. However, a better understanding of the complex immunological networks of LC is required to improve immunotherapy efficacy further. Tumor-associated antigens (TAAs) and tumor-specific antigens (TSAs) are significantly expressed by LC cells, which activate dendritic cells, initiate antigen presentation, and activate lymphocytes to exert antitumor activity. However, as tumor cells combat the immune system, an immunosuppressive microenvironment forms, enabling the enactment of a series of immunological escape mechanisms, including the recruitment of immunosuppressive cells and induction of T cell exhaustion to decrease the antitumor immune response. In addition to the direct effect of LC cells on immune cell function, the secreting various cytokines, chemokines, and exosomes, changes in the intratumoral microbiome and the function of cancer-associated fibroblasts and endothelial cells contribute to LC cell immune escape. Accordingly, combining various immunotherapies with other therapies can elicit synergistic effects based on the complex immune network, improving immunotherapy efficacy through multi-target action on the tumor microenvironment (TME). Hence, this review provides guidance for understanding the complex immune network in the TME and designing novel and effective immunotherapy strategies for LC. |
| first_indexed | 2024-03-12T01:11:17Z |
| format | Article |
| id | doaj.art-f808af9f1d884975a565280ca03ae91d |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T01:11:17Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-f808af9f1d884975a565280ca03ae91d2023-09-14T04:52:41ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-10-01166115336Non-immune cell components in tumor microenvironment influencing lung cancer ImmunotherapyJingtao Zhang0Shuai Liu1Xiubao Chen2Xiangdong Xu3Fei Xu4College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaCentral Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaDepartment of Geriatric Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaCentral Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China; Correspondence to: Central Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.Department of Geriatric Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China; Correspondence to: Department of Geriatric Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.Lung cancer (LC) is one of the leading causes of cancer-related deaths worldwide, with a significant morbidity and mortality rate, endangering human life and health. The introduction of immunotherapies has significantly altered existing cancer treatment strategies and is expected to improve immune responses, objective response rates, and survival rates. However, a better understanding of the complex immunological networks of LC is required to improve immunotherapy efficacy further. Tumor-associated antigens (TAAs) and tumor-specific antigens (TSAs) are significantly expressed by LC cells, which activate dendritic cells, initiate antigen presentation, and activate lymphocytes to exert antitumor activity. However, as tumor cells combat the immune system, an immunosuppressive microenvironment forms, enabling the enactment of a series of immunological escape mechanisms, including the recruitment of immunosuppressive cells and induction of T cell exhaustion to decrease the antitumor immune response. In addition to the direct effect of LC cells on immune cell function, the secreting various cytokines, chemokines, and exosomes, changes in the intratumoral microbiome and the function of cancer-associated fibroblasts and endothelial cells contribute to LC cell immune escape. Accordingly, combining various immunotherapies with other therapies can elicit synergistic effects based on the complex immune network, improving immunotherapy efficacy through multi-target action on the tumor microenvironment (TME). Hence, this review provides guidance for understanding the complex immune network in the TME and designing novel and effective immunotherapy strategies for LC.http://www.sciencedirect.com/science/article/pii/S0753332223011277ImmunotherapyLCTMETumor vaccineICIsAdoptive T cell therapy |
| spellingShingle | Jingtao Zhang Shuai Liu Xiubao Chen Xiangdong Xu Fei Xu Non-immune cell components in tumor microenvironment influencing lung cancer Immunotherapy Biomedicine & Pharmacotherapy Immunotherapy LC TME Tumor vaccine ICIs Adoptive T cell therapy |
| title | Non-immune cell components in tumor microenvironment influencing lung cancer Immunotherapy |
| title_full | Non-immune cell components in tumor microenvironment influencing lung cancer Immunotherapy |
| title_fullStr | Non-immune cell components in tumor microenvironment influencing lung cancer Immunotherapy |
| title_full_unstemmed | Non-immune cell components in tumor microenvironment influencing lung cancer Immunotherapy |
| title_short | Non-immune cell components in tumor microenvironment influencing lung cancer Immunotherapy |
| title_sort | non immune cell components in tumor microenvironment influencing lung cancer immunotherapy |
| topic | Immunotherapy LC TME Tumor vaccine ICIs Adoptive T cell therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223011277 |
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