Reproducibility in animal models of hypertension: a difficult problem
Abstract In 2016, the National Institutes of Health mandated that all grant proposals enhance reproducibility through rigor and transparency. In the past few years, physiological outcomes in established animal models of hypertension, in particular in regard to sex differences, have varied from study...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Biology of Sex Differences |
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| Online Access: | http://link.springer.com/article/10.1186/s13293-018-0216-4 |
| _version_ | 1811318404632543232 |
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| author | Jane F. Reckelhoff Barbara T. Alexander |
| author_facet | Jane F. Reckelhoff Barbara T. Alexander |
| author_sort | Jane F. Reckelhoff |
| collection | DOAJ |
| description | Abstract In 2016, the National Institutes of Health mandated that all grant proposals enhance reproducibility through rigor and transparency. In the past few years, physiological outcomes in established animal models of hypertension, in particular in regard to sex differences, have varied from study to study or laboratory to laboratory. The aim of this commentary is to increase investigator awareness of caveats related to animal models that may be sensitive to vendor-, barrier-, or diet-specific changes that result in an inability to sustain the genotype and/or phenotype of well-established experimental models. These considerations are critical in order for investigators to make informed and educated decisions in regard to their hypothesis-driven research, in particular as it relates to experimental design and interpretation, and the reporting of results. |
| first_indexed | 2024-04-13T12:25:43Z |
| format | Article |
| id | doaj.art-f808f59e390e41258dffc840abf5055f |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-13T12:25:43Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-f808f59e390e41258dffc840abf5055f2022-12-22T02:47:03ZengBMCBiology of Sex Differences2042-64102018-12-01911410.1186/s13293-018-0216-4Reproducibility in animal models of hypertension: a difficult problemJane F. Reckelhoff0Barbara T. Alexander1Department of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Physiology, University of Mississippi Medical CenterAbstract In 2016, the National Institutes of Health mandated that all grant proposals enhance reproducibility through rigor and transparency. In the past few years, physiological outcomes in established animal models of hypertension, in particular in regard to sex differences, have varied from study to study or laboratory to laboratory. The aim of this commentary is to increase investigator awareness of caveats related to animal models that may be sensitive to vendor-, barrier-, or diet-specific changes that result in an inability to sustain the genotype and/or phenotype of well-established experimental models. These considerations are critical in order for investigators to make informed and educated decisions in regard to their hypothesis-driven research, in particular as it relates to experimental design and interpretation, and the reporting of results.http://link.springer.com/article/10.1186/s13293-018-0216-4Dahl salt-sensitive ratSpontaneously hypertensive ratRag-1 knockout mouse |
| spellingShingle | Jane F. Reckelhoff Barbara T. Alexander Reproducibility in animal models of hypertension: a difficult problem Biology of Sex Differences Dahl salt-sensitive rat Spontaneously hypertensive rat Rag-1 knockout mouse |
| title | Reproducibility in animal models of hypertension: a difficult problem |
| title_full | Reproducibility in animal models of hypertension: a difficult problem |
| title_fullStr | Reproducibility in animal models of hypertension: a difficult problem |
| title_full_unstemmed | Reproducibility in animal models of hypertension: a difficult problem |
| title_short | Reproducibility in animal models of hypertension: a difficult problem |
| title_sort | reproducibility in animal models of hypertension a difficult problem |
| topic | Dahl salt-sensitive rat Spontaneously hypertensive rat Rag-1 knockout mouse |
| url | http://link.springer.com/article/10.1186/s13293-018-0216-4 |
| work_keys_str_mv | AT janefreckelhoff reproducibilityinanimalmodelsofhypertensionadifficultproblem AT barbaratalexander reproducibilityinanimalmodelsofhypertensionadifficultproblem |