Public health and budget impacts of switching from a trivalent to a quadrivalent inactivated influenza vaccine in Paraguay
This study aimed to investigate the public health and economic benefit of using a quadrivalent influenza vaccine (QIV) instead of a trivalent influenza vaccine (TIV) in past seasons in Paraguay. The budget impact of switching from TIV to QIV in the Immunization Program was also evaluated. The adapte...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-11-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2022.2069974 |
| _version_ | 1797673215338741760 |
|---|---|
| author | Antonio Arbo Celia Martinez-Cuellar Cynthia Vazquez Lucile Bellier Cecilia Adorno Hugo Dibarboure Juan Guillermo Lopez Audrey Petitjean Pablo Bianculli |
| author_facet | Antonio Arbo Celia Martinez-Cuellar Cynthia Vazquez Lucile Bellier Cecilia Adorno Hugo Dibarboure Juan Guillermo Lopez Audrey Petitjean Pablo Bianculli |
| author_sort | Antonio Arbo |
| collection | DOAJ |
| description | This study aimed to investigate the public health and economic benefit of using a quadrivalent influenza vaccine (QIV) instead of a trivalent influenza vaccine (TIV) in past seasons in Paraguay. The budget impact of switching from TIV to QIV in the Immunization Program was also evaluated. The adapted model includes two modules. The first compared retrospectively Health and Economic outcomes resulting from the use of QIV instead of TIV. The second forecast the spending and savings that would be associated with the switch from TIV to QIV. Our findings estimate that the switch from TIV to QIV during the seasons 2012 to 2017 could have prevented around 2,600 influenza cases, 67 hospitalizations and 10 deaths. An alternative scenario using standardized estimates of the burden of influenza showed that 234 influenza-related hospitalizations and 29 deaths could have been prevented. The estimated annual budget impact of a full switch from TIV to QIV was around USD1,6 million both from the payer and societal perspectives. Those results are mainly driven by vaccine prices and coverage rate. In sum, this manuscript describes how the use of QIV instead of TIV could have prevented influenza cases and subsequent complications that led to hospitalizations and deaths. This could have generated savings for the health system and society, offsetting part of the additional investment needed to switch from TIV to QIV. |
| first_indexed | 2024-03-11T21:41:16Z |
| format | Article |
| id | doaj.art-f8099cd98bb742bca78d871338360d55 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:41:16Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-f8099cd98bb742bca78d871338360d552023-09-26T13:19:06ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2022-11-0118510.1080/21645515.2022.20699742069974Public health and budget impacts of switching from a trivalent to a quadrivalent inactivated influenza vaccine in ParaguayAntonio Arbo0Celia Martinez-Cuellar1Cynthia Vazquez2Lucile Bellier3Cecilia Adorno4Hugo Dibarboure5Juan Guillermo Lopez6Audrey Petitjean7Pablo Bianculli8National University of ParaguayNational University of ParaguayLaboratorio Central de Salud PúblicaCreativ-CeuticalSanofi PasteurSanofi Pasteur South ConeSanofiSanofi PasteurSanofi Pasteur South ConeThis study aimed to investigate the public health and economic benefit of using a quadrivalent influenza vaccine (QIV) instead of a trivalent influenza vaccine (TIV) in past seasons in Paraguay. The budget impact of switching from TIV to QIV in the Immunization Program was also evaluated. The adapted model includes two modules. The first compared retrospectively Health and Economic outcomes resulting from the use of QIV instead of TIV. The second forecast the spending and savings that would be associated with the switch from TIV to QIV. Our findings estimate that the switch from TIV to QIV during the seasons 2012 to 2017 could have prevented around 2,600 influenza cases, 67 hospitalizations and 10 deaths. An alternative scenario using standardized estimates of the burden of influenza showed that 234 influenza-related hospitalizations and 29 deaths could have been prevented. The estimated annual budget impact of a full switch from TIV to QIV was around USD1,6 million both from the payer and societal perspectives. Those results are mainly driven by vaccine prices and coverage rate. In sum, this manuscript describes how the use of QIV instead of TIV could have prevented influenza cases and subsequent complications that led to hospitalizations and deaths. This could have generated savings for the health system and society, offsetting part of the additional investment needed to switch from TIV to QIV.http://dx.doi.org/10.1080/21645515.2022.2069974paraguaybudget impactvaccine switchtrivalent vaccinequadrivalent vaccineinfluenzapublic health impact |
| spellingShingle | Antonio Arbo Celia Martinez-Cuellar Cynthia Vazquez Lucile Bellier Cecilia Adorno Hugo Dibarboure Juan Guillermo Lopez Audrey Petitjean Pablo Bianculli Public health and budget impacts of switching from a trivalent to a quadrivalent inactivated influenza vaccine in Paraguay Human Vaccines & Immunotherapeutics paraguay budget impact vaccine switch trivalent vaccine quadrivalent vaccine influenza public health impact |
| title | Public health and budget impacts of switching from a trivalent to a quadrivalent inactivated influenza vaccine in Paraguay |
| title_full | Public health and budget impacts of switching from a trivalent to a quadrivalent inactivated influenza vaccine in Paraguay |
| title_fullStr | Public health and budget impacts of switching from a trivalent to a quadrivalent inactivated influenza vaccine in Paraguay |
| title_full_unstemmed | Public health and budget impacts of switching from a trivalent to a quadrivalent inactivated influenza vaccine in Paraguay |
| title_short | Public health and budget impacts of switching from a trivalent to a quadrivalent inactivated influenza vaccine in Paraguay |
| title_sort | public health and budget impacts of switching from a trivalent to a quadrivalent inactivated influenza vaccine in paraguay |
| topic | paraguay budget impact vaccine switch trivalent vaccine quadrivalent vaccine influenza public health impact |
| url | http://dx.doi.org/10.1080/21645515.2022.2069974 |
| work_keys_str_mv | AT antonioarbo publichealthandbudgetimpactsofswitchingfromatrivalenttoaquadrivalentinactivatedinfluenzavaccineinparaguay AT celiamartinezcuellar publichealthandbudgetimpactsofswitchingfromatrivalenttoaquadrivalentinactivatedinfluenzavaccineinparaguay AT cynthiavazquez publichealthandbudgetimpactsofswitchingfromatrivalenttoaquadrivalentinactivatedinfluenzavaccineinparaguay AT lucilebellier publichealthandbudgetimpactsofswitchingfromatrivalenttoaquadrivalentinactivatedinfluenzavaccineinparaguay AT ceciliaadorno publichealthandbudgetimpactsofswitchingfromatrivalenttoaquadrivalentinactivatedinfluenzavaccineinparaguay AT hugodibarboure publichealthandbudgetimpactsofswitchingfromatrivalenttoaquadrivalentinactivatedinfluenzavaccineinparaguay AT juanguillermolopez publichealthandbudgetimpactsofswitchingfromatrivalenttoaquadrivalentinactivatedinfluenzavaccineinparaguay AT audreypetitjean publichealthandbudgetimpactsofswitchingfromatrivalenttoaquadrivalentinactivatedinfluenzavaccineinparaguay AT pablobianculli publichealthandbudgetimpactsofswitchingfromatrivalenttoaquadrivalentinactivatedinfluenzavaccineinparaguay |