Fibulin 2 Is Hypermethylated and Suppresses Tumor Cell Proliferation through Inhibition of Cell Adhesion and Extracellular Matrix Genes in Non-Small Cell Lung Cancer

Fibulin 2 Is Hypermethylated and Suppresses Tumor Cell Proliferation through Inhibition of Cell Adhesion and Extracellular Matrix Genes in Non-Small Cell Lung Cancer

Fibulins (FBLNs), interacting with cell adhesion receptors and extracellular matrix (ECM) components, play multiple roles in ECM structures and tissue functions. Abnormal expression of FBLN2, one of the fibulin family members, contributes to tumor initiation and development. However, the function of...

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Bibliographic Details
Main Authors: Yunxia Ma, Miljana Nenkov, Desiree Charlotte Schröder, Mohamed Abubrig, Nikolaus Gassler, Yuan Chen
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
NSCLC
FBLN2
DNA methylation
cell adhesion
ECM
Online Access:https://www.mdpi.com/1422-0067/22/21/11834

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