Isolation of a Virulent <i>Clostridium perfringens</i> Strain from <i>Elaphurus davidianus</i> and Characterization by Whole-Genome Sequence Analysis

Isolation of a Virulent <i>Clostridium perfringens</i> Strain from <i>Elaphurus davidianus</i> and Characterization by Whole-Genome Sequence Analysis

<i>Clostridium perfringens</i> (<i>C. perfringens</i>) is an important veterinary pathogen and a noteworthy threat to human and animal health. Recently, there has been a significant rise in the number of moose fatalities caused by this rare, endemic species in China. Currentl...

詳細記述

書誌詳細
主要な著者: Zhao Zhang, Xiao Wang, Siyuan Li, Yuhang Fu, Yan Li, Shah Nawaz, Jing Chen, Guoxiang Yang, Jiakui Li, Daoliang Shi
フォーマット: 論文
言語:English
出版事項: MDPI AG 2024-07-01
シリーズ:Current Issues in Molecular Biology
主題:
<i>Elaphurus davidianus</i>
<i>Clostridium perfringens</i>
whole-genome sequencing analysis
comparative genome
オンライン･アクセス:https://www.mdpi.com/1467-3045/46/7/427
その他の書誌記述
要約:<i>Clostridium perfringens</i> (<i>C. perfringens</i>) is an important veterinary pathogen and a noteworthy threat to human and animal health. Recently, there has been a significant rise in the number of moose fatalities caused by this rare, endemic species in China. Currently, there is an increasing trend in conducting whole-genome analysis of <i>C. perfringens</i> strains originating from pigs and chickens, whereas fewer studies have been undertaken on <i>Elaphurus davidianus</i>-originating strains at the whole-genome level. Our laboratory has identified and isolated five <i>C. perfringens</i> type A from affected <i>Elaphurus davidianus.</i> The current study identified the most potent strain of <i>C. perfringens,</i> which originated from <i>Elaphurus davidianus</i>, and sequenced its genome to reveal virulence genes and pathogenicity. Our findings show that strain CX1-4 exhibits the highest levels of phospholipase activity, hemolytic activity, and mouse toxicity compared to the other four isolated <i>C. perfringens</i> type A strains. The chromosome sequence length of the CX1-4 strain was found to be 3,355,389 bp by complete genome sequencing. The current study unveils the genomic characteristics of <i>C. perfringens</i> type A originating from <i>Elaphurus davidianus</i>. It provides a core foundation for further investigation regarding the prevention and treatment of such infectious diseases in <i>Elaphurus davidianus</i>.
ISSN:1467-3037
1467-3045

類似資料