Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox

Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox

To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead to their repair. Collectively, these signaling ne...

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Bibliographic Details
Main Authors: Alexandra C. Vítor, Pablo Huertas, Gaëlle Legube, Sérgio F. de Almeida
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
DNA repair
homologous recombination (HR)
non-homologous DNA end joining
chromatin
DNA damage
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00024/full

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