Significance of STAT3 in Immune Infiltration and Drug Response in Cancer
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and regulates tumorigenesis. However, the functions of STAT3 in immune and drug response in cancer remain elusive. Hence, we aim to reveal the impact of STAT3 in immune infiltration and drug response comprehensively...
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MDPI AG
2020-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/6/834 |
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| author | Wei Chen Xiaoshuo Dai Yihuan Chen Fang Tian Yanyan Zhang Qiushuang Zhang Jing Lu |
| author_facet | Wei Chen Xiaoshuo Dai Yihuan Chen Fang Tian Yanyan Zhang Qiushuang Zhang Jing Lu |
| author_sort | Wei Chen |
| collection | DOAJ |
| description | Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and regulates tumorigenesis. However, the functions of STAT3 in immune and drug response in cancer remain elusive. Hence, we aim to reveal the impact of STAT3 in immune infiltration and drug response comprehensively by bioinformatics analysis. The expression of STAT3 and its relationship with tumor stage were explored by Tumor Immune Estimation Resource (TIMER), Human Protein Altas (HPA), and UALCAN databases. The correlations between STAT3 and immune infiltration, gene markers of immune cells were analyzed by TIMER. Moreover, the association between STAT3 and drug response was evaluated by the Cancer Cell Line Encyclopedia (CCLE) and Cancer Therapeutics Response Portal (CTRP). The results suggested that the mRNA transcriptional level of STAT3 was lower in tumors than normal tissues and mostly unrelated to tumor stage. Besides, the protein expression of STAT3 decreased in colorectal and renal cancer compared with normal tissues. Importantly, STAT3 was correlated with immune infiltration and particularly regulated tumor-associated macrophage (TAM), M2 macrophage, T-helper 1 (Th1), follicular helper T (Treg), and exhausted T-cells. Remarkably, STAT3 was closely correlated with the response to specified inhibitors and natural compounds in cancer. Furthermore, the association between STAT3 and drug response was highly cell line type dependent. Significantly, the study provides thorough insight that STAT3 is associated with immunosuppression, as well as drug response in clinical treatment. |
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| format | Article |
| id | doaj.art-f8123ef5d75d4e1d8465c42ed620b487 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T19:30:11Z |
| publishDate | 2020-05-01 |
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| spelling | doaj.art-f8123ef5d75d4e1d8465c42ed620b4872023-11-20T02:12:10ZengMDPI AGBiomolecules2218-273X2020-05-0110683410.3390/biom10060834Significance of STAT3 in Immune Infiltration and Drug Response in CancerWei Chen0Xiaoshuo Dai1Yihuan Chen2Fang Tian3Yanyan Zhang4Qiushuang Zhang5Jing Lu6Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, ChinaSignal transducer and activator of transcription 3 (STAT3) is a transcription factor and regulates tumorigenesis. However, the functions of STAT3 in immune and drug response in cancer remain elusive. Hence, we aim to reveal the impact of STAT3 in immune infiltration and drug response comprehensively by bioinformatics analysis. The expression of STAT3 and its relationship with tumor stage were explored by Tumor Immune Estimation Resource (TIMER), Human Protein Altas (HPA), and UALCAN databases. The correlations between STAT3 and immune infiltration, gene markers of immune cells were analyzed by TIMER. Moreover, the association between STAT3 and drug response was evaluated by the Cancer Cell Line Encyclopedia (CCLE) and Cancer Therapeutics Response Portal (CTRP). The results suggested that the mRNA transcriptional level of STAT3 was lower in tumors than normal tissues and mostly unrelated to tumor stage. Besides, the protein expression of STAT3 decreased in colorectal and renal cancer compared with normal tissues. Importantly, STAT3 was correlated with immune infiltration and particularly regulated tumor-associated macrophage (TAM), M2 macrophage, T-helper 1 (Th1), follicular helper T (Treg), and exhausted T-cells. Remarkably, STAT3 was closely correlated with the response to specified inhibitors and natural compounds in cancer. Furthermore, the association between STAT3 and drug response was highly cell line type dependent. Significantly, the study provides thorough insight that STAT3 is associated with immunosuppression, as well as drug response in clinical treatment.https://www.mdpi.com/2218-273X/10/6/834STAT3immune infiltrationdrug responsebioinformatics |
| spellingShingle | Wei Chen Xiaoshuo Dai Yihuan Chen Fang Tian Yanyan Zhang Qiushuang Zhang Jing Lu Significance of STAT3 in Immune Infiltration and Drug Response in Cancer Biomolecules STAT3 immune infiltration drug response bioinformatics |
| title | Significance of STAT3 in Immune Infiltration and Drug Response in Cancer |
| title_full | Significance of STAT3 in Immune Infiltration and Drug Response in Cancer |
| title_fullStr | Significance of STAT3 in Immune Infiltration and Drug Response in Cancer |
| title_full_unstemmed | Significance of STAT3 in Immune Infiltration and Drug Response in Cancer |
| title_short | Significance of STAT3 in Immune Infiltration and Drug Response in Cancer |
| title_sort | significance of stat3 in immune infiltration and drug response in cancer |
| topic | STAT3 immune infiltration drug response bioinformatics |
| url | https://www.mdpi.com/2218-273X/10/6/834 |
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