Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive rats
Cardiac hypertrophy that accompanies hypertension seems to be a phenomenon of multifactorial origin whose development does not seem to depend on an increased pressure load alone, but also on local growth factors and cardioadrenergic activity. The aim of the present study was to determine if sympathe...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1998-04-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400018 |
| _version_ | 1819021589320040448 |
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| author | A.M. Cabral I.F. Silva C.R. Gardioli H. Mauad E.C. Vasquez |
| author_facet | A.M. Cabral I.F. Silva C.R. Gardioli H. Mauad E.C. Vasquez |
| author_sort | A.M. Cabral |
| collection | DOAJ |
| description | Cardiac hypertrophy that accompanies hypertension seems to be a phenomenon of multifactorial origin whose development does not seem to depend on an increased pressure load alone, but also on local growth factors and cardioadrenergic activity. The aim of the present study was to determine if sympathetic renal denervation and its effects on arterial pressure level can prevent cardiac hypertrophy and if it can also delay the onset and attenuate the severity of deoxycorticosterone acetate (DOCA)-salt hypertension. DOCA-salt treatment was initiated in rats seven days after uninephrectomy and contralateral renal denervation or sham renal denervation. DOCA (15 mg/kg, sc) or vehicle (soybean oil, 0.25 ml per animal) was administered twice a week for two weeks. Rats treated with DOCA or vehicle (control) were provided drinking water containing 1% NaCl and 0.03% KCl. At the end of the treatment period, mean arterial pressure (MAP) and heart rate measurements were made in conscious animals. Under ether anesthesia, the heart was removed and the right and left ventricles (including the septum) were separated and weighed. DOCA-salt treatment produced a significant increase in left ventricular weight/body weight (LVW/BW) ratio (2.44 ± 0.09 mg/g) and right ventricular weight/body weight (RVW/BW) ratio (0.53 ± 0.01 mg/g) compared to control (1.92 ± 0.04 and 0.48 ± 0.01 mg/g, respectively) rats. MAP was significantly higher (39%) in DOCA-salt rats. Renal denervation prevented (P>0.05) the development of hypertension in DOCA-salt rats but did not prevent the increase in LVW/BW (2.27 ± 0.03 mg/g) and RVW/BW (0.52 ± 0.01 mg/g). We have shown that the increase in arterial pressure level is not responsible for cardiac hypertrophy, which may be more related to other events associated with DOCA-salt hypertension, such as an increase in cardiac sympathetic activity |
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| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-21T04:09:30Z |
| publishDate | 1998-04-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-f8126526786749b98e6b3675ac61f5a42022-12-21T19:16:31ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1998-04-0131458710.1590/S0100-879X1998000400018Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive ratsA.M. CabralI.F. SilvaC.R. GardioliH. MauadE.C. VasquezCardiac hypertrophy that accompanies hypertension seems to be a phenomenon of multifactorial origin whose development does not seem to depend on an increased pressure load alone, but also on local growth factors and cardioadrenergic activity. The aim of the present study was to determine if sympathetic renal denervation and its effects on arterial pressure level can prevent cardiac hypertrophy and if it can also delay the onset and attenuate the severity of deoxycorticosterone acetate (DOCA)-salt hypertension. DOCA-salt treatment was initiated in rats seven days after uninephrectomy and contralateral renal denervation or sham renal denervation. DOCA (15 mg/kg, sc) or vehicle (soybean oil, 0.25 ml per animal) was administered twice a week for two weeks. Rats treated with DOCA or vehicle (control) were provided drinking water containing 1% NaCl and 0.03% KCl. At the end of the treatment period, mean arterial pressure (MAP) and heart rate measurements were made in conscious animals. Under ether anesthesia, the heart was removed and the right and left ventricles (including the septum) were separated and weighed. DOCA-salt treatment produced a significant increase in left ventricular weight/body weight (LVW/BW) ratio (2.44 ± 0.09 mg/g) and right ventricular weight/body weight (RVW/BW) ratio (0.53 ± 0.01 mg/g) compared to control (1.92 ± 0.04 and 0.48 ± 0.01 mg/g, respectively) rats. MAP was significantly higher (39%) in DOCA-salt rats. Renal denervation prevented (P>0.05) the development of hypertension in DOCA-salt rats but did not prevent the increase in LVW/BW (2.27 ± 0.03 mg/g) and RVW/BW (0.52 ± 0.01 mg/g). We have shown that the increase in arterial pressure level is not responsible for cardiac hypertrophy, which may be more related to other events associated with DOCA-salt hypertension, such as an increase in cardiac sympathetic activityhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400018ventricular hypertrophyrenal denervationDOCA-salt hypertensionblood pressure |
| spellingShingle | A.M. Cabral I.F. Silva C.R. Gardioli H. Mauad E.C. Vasquez Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive rats Brazilian Journal of Medical and Biological Research ventricular hypertrophy renal denervation DOCA-salt hypertension blood pressure |
| title | Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive rats |
| title_full | Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive rats |
| title_fullStr | Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive rats |
| title_full_unstemmed | Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive rats |
| title_short | Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive rats |
| title_sort | diverse effects of renal denervation on ventricular hypertrophy and blood pressure in doca salt hypertensive rats |
| topic | ventricular hypertrophy renal denervation DOCA-salt hypertension blood pressure |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400018 |
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