Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study
Abstract Background The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed congestive heart failure (CHF). Objectives To describe the changes in clinical an...
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| Format: | Article |
| Language: | English |
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Wiley
2020-05-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15753 |
| _version_ | 1818923170318516224 |
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| author | Adrian Boswood Sonya G. Gordon Jens Häggström Martin Vanselow Gerhard Wess Rebecca L. Stepien Mark A. Oyama Bruce W. Keene John Bonagura Kristin A. MacDonald Mark Patteson Sarah Smith Philip R. Fox Karen Sanderson Richard Woolley Viktor Szatmári Pierre Menaut Whitney M. Church M. Lynne O'Sullivan Jean‐Philippe Jaudon Jan‐Gerd Kresken John Rush Kirstie A. Barrett Steven L. Rosenthal Ashley B. Saunders Ingrid Ljungvall Michael Deinert Eric Bomassi Amara H. Estrada Maria J. Fernandez Del Palacio N. Sydney Moise Jonathan A. Abbott Yoko Fujii Alan Spier Michael W. Luethy Roberto A. Santilli Masami Uechi Anna Tidholm Christoph Schummer Philip Watson |
| author_facet | Adrian Boswood Sonya G. Gordon Jens Häggström Martin Vanselow Gerhard Wess Rebecca L. Stepien Mark A. Oyama Bruce W. Keene John Bonagura Kristin A. MacDonald Mark Patteson Sarah Smith Philip R. Fox Karen Sanderson Richard Woolley Viktor Szatmári Pierre Menaut Whitney M. Church M. Lynne O'Sullivan Jean‐Philippe Jaudon Jan‐Gerd Kresken John Rush Kirstie A. Barrett Steven L. Rosenthal Ashley B. Saunders Ingrid Ljungvall Michael Deinert Eric Bomassi Amara H. Estrada Maria J. Fernandez Del Palacio N. Sydney Moise Jonathan A. Abbott Yoko Fujii Alan Spier Michael W. Luethy Roberto A. Santilli Masami Uechi Anna Tidholm Christoph Schummer Philip Watson |
| author_sort | Adrian Boswood |
| collection | DOAJ |
| description | Abstract Background The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed congestive heart failure (CHF). Objectives To describe the changes in clinical and radiographic variables occurring as dogs with MMVD and cardiomegaly develop CHF, compared to similar dogs that do not develop CHF. Animals One hundred and thirty‐five, and 73 dogs that did or did not develop CHF, respectively. Materials and methods The following variables were evaluated in 2 groups of dogs (dogs that did or did not develop CHF): Heart rate (HR), clinic respiratory rate (RR), home‐measured resting respiratory rate (RRR), rectal temperature (RT), body weight (BW), and vertebral heart sum (VHS). Absolute value and rate of change of each variable were calculated for each day a dog was in study. Daily means were calculated and plotted against time. The onset of CHF or last visit before leaving the study were set as reference time points. Results The most extreme values and rate of change occurred in variables immediately before onset of CHF. Vertebral heart sum increased earliest. Heart rate, RR, and RRR also increased. Rectal temperature and BW decreased. Increases in RR and RRR were most extreme and occurred immediately before CHF. Conclusions and Clinical Importance Dogs with MMVD and cardiomegaly experience increases in HR, RR, RRR, and VHS, and decreases in BW and RT as they develop CHF. The variables with highest absolute change and rate of change were RR and RRR. These findings reinforce the value of RR and RRR as indicators of impending or incipient CHF. |
| first_indexed | 2024-12-20T02:05:11Z |
| format | Article |
| id | doaj.art-f816a01d6c2348de83f7544ce3fb739b |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-20T02:05:11Z |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-f816a01d6c2348de83f7544ce3fb739b2022-12-21T19:57:14ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762020-05-013431108111810.1111/jvim.15753Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC studyAdrian Boswood0Sonya G. Gordon1Jens Häggström2Martin Vanselow3Gerhard Wess4Rebecca L. Stepien5Mark A. Oyama6Bruce W. Keene7John Bonagura8Kristin A. MacDonald9Mark Patteson10Sarah Smith11Philip R. Fox12Karen Sanderson13Richard Woolley14Viktor Szatmári15Pierre Menaut16Whitney M. Church17M. Lynne O'Sullivan18Jean‐Philippe Jaudon19Jan‐Gerd Kresken20John Rush21Kirstie A. Barrett22Steven L. Rosenthal23Ashley B. Saunders24Ingrid Ljungvall25Michael Deinert26Eric Bomassi27Amara H. Estrada28Maria J. Fernandez Del Palacio29N. Sydney Moise30Jonathan A. Abbott31Yoko Fujii32Alan Spier33Michael W. Luethy34Roberto A. Santilli35Masami Uechi36Anna Tidholm37Christoph Schummer38Philip Watson39Department of Clinical Science and Services, The Royal Veterinary College Hatfield, Hertfordshire UKDepartment of Small Animal Clinical Sciences, Texas A&M University College Station TexasDepartment of Clinical Sciences Swedish University of Agricultural Sciences Uppsala SwedenBiometrie and Statistik, Hannover GermanyClinic of Small Animal Medicine University of Munich Munich GermanySchool of Veterinary Medicine, Medical Sciences University of Wisconsin Madison Madison WisconsinClinical Studies‐Philadelphia, MJR‐VHUP‐Cardiology University of Pennsylvania Philadelphia PennsylvaniaDepartment of Clinical Sciences North Carolina State University, College of Veterinary Medicine Raleigh North CarolinaDepartment of Veterinary Clinical Sciences The Ohio State University Columbus OhioAnimal Care Center Rohnert Park CaliforniaHeartVets @ Vale Referrals, The Animal Hospital Stinchcombe, Dursley Glos UKSarah Smith Cardiology Derby UKDepartment of Cardiology and Caspary Research Institute, Animal Medical Center New York New YorkRocky Mountain Veterinary Cardiology Boulder ColoradoCardio Respiratory Pet Referrals Mordialloc, Melbourne Victoria AustraliaFaculty of Veterinary Medicine, Clinical Sciences of Companion Animals Utrecht University Utrecht The NetherlandsClinique Vétérinaire AQUIVET Eysines FranceDesert Veterinary Medical Specialists Phoenix ArizonaDepartment of Companion Animals Atlantic Veterinary College, University of Prince Edward Island Charlottetown Prince Edward Island CanadaClinique Veterinaire Des Etangs Villars Les Dombes FranceClinic for Small Animals Kaiserberg Duisburg GermanySchool of Veterinary Medicine, Clinical Sciences Tufts University Cummings North Grafton MassachusettsCardiology VCA West Los Angeles Los Angeles CaliforniaCVCA Cardiac Care for Pets Towson MarylandDepartment of Small Animal Clinical Sciences, Texas A&M University College Station TexasDepartment of Clinical Sciences Swedish University of Agricultural Sciences Uppsala SwedenFachtierarztpraxis Am Sandpfad Wiesloch GermanyCentre Hospitalier Vétérinaire des Cordeliers, Cardiology, Meaux Paris FranceUniversity of Florida College of Veterinary Medicine, Small Animal Clinical Sciences Gainesville FloridaMedicina y Cirugía Animal Universidad de Murcia Murcia SpainClinical Sciences, College of Veterinary Medicine Cornell University Ithaca New YorkDepartment of Small Animal Clinical Sciences Virginia‐Maryland College of Veterinary Medicine, Virginia Tech Blacksburg VirginiaAzabu University, Surgery 1 Kanagawa JapanBlue Pearl Veterinary Partners Tampa FloridaChicago Veterinary Emergency and Specialty Center Chicago IllinoisCardiology Clinica Veterinaria Malpensa Varese ItalyJapan Animal Specialty Medical Institute Inc., JASMINE Veterinary Cardiovascular Medical Center Yokohama JapanDjursjukhuset Albano Stockholm SwedenBoehringer Ingelheim, Animal Health Ingelheim am Rhein GermanyBoehringer Ingelheim, Animal Health Ingelheim am Rhein GermanyAbstract Background The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed congestive heart failure (CHF). Objectives To describe the changes in clinical and radiographic variables occurring as dogs with MMVD and cardiomegaly develop CHF, compared to similar dogs that do not develop CHF. Animals One hundred and thirty‐five, and 73 dogs that did or did not develop CHF, respectively. Materials and methods The following variables were evaluated in 2 groups of dogs (dogs that did or did not develop CHF): Heart rate (HR), clinic respiratory rate (RR), home‐measured resting respiratory rate (RRR), rectal temperature (RT), body weight (BW), and vertebral heart sum (VHS). Absolute value and rate of change of each variable were calculated for each day a dog was in study. Daily means were calculated and plotted against time. The onset of CHF or last visit before leaving the study were set as reference time points. Results The most extreme values and rate of change occurred in variables immediately before onset of CHF. Vertebral heart sum increased earliest. Heart rate, RR, and RRR also increased. Rectal temperature and BW decreased. Increases in RR and RRR were most extreme and occurred immediately before CHF. Conclusions and Clinical Importance Dogs with MMVD and cardiomegaly experience increases in HR, RR, RRR, and VHS, and decreases in BW and RT as they develop CHF. The variables with highest absolute change and rate of change were RR and RRR. These findings reinforce the value of RR and RRR as indicators of impending or incipient CHF.https://doi.org/10.1111/jvim.15753caninecardiovascularclinical epidemiologyclinical trialsheart failurephysical examination |
| spellingShingle | Adrian Boswood Sonya G. Gordon Jens Häggström Martin Vanselow Gerhard Wess Rebecca L. Stepien Mark A. Oyama Bruce W. Keene John Bonagura Kristin A. MacDonald Mark Patteson Sarah Smith Philip R. Fox Karen Sanderson Richard Woolley Viktor Szatmári Pierre Menaut Whitney M. Church M. Lynne O'Sullivan Jean‐Philippe Jaudon Jan‐Gerd Kresken John Rush Kirstie A. Barrett Steven L. Rosenthal Ashley B. Saunders Ingrid Ljungvall Michael Deinert Eric Bomassi Amara H. Estrada Maria J. Fernandez Del Palacio N. Sydney Moise Jonathan A. Abbott Yoko Fujii Alan Spier Michael W. Luethy Roberto A. Santilli Masami Uechi Anna Tidholm Christoph Schummer Philip Watson Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study Journal of Veterinary Internal Medicine canine cardiovascular clinical epidemiology clinical trials heart failure physical examination |
| title | Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study |
| title_full | Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study |
| title_fullStr | Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study |
| title_full_unstemmed | Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study |
| title_short | Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study |
| title_sort | temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease the epic study |
| topic | canine cardiovascular clinical epidemiology clinical trials heart failure physical examination |
| url | https://doi.org/10.1111/jvim.15753 |
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