Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity
Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics. Both palmitoylation by palmitoyl acyl transferases (PAT) and depalmitoylation by palmitoyl-prot...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-01-01
|
| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnmol.2019.00008/full |
| _version_ | 1818507996993421312 |
|---|---|
| author | Lucas Matt Karam Kim Dhrubajyoti Chowdhury Johannes W. Hell |
| author_facet | Lucas Matt Karam Kim Dhrubajyoti Chowdhury Johannes W. Hell |
| author_sort | Lucas Matt |
| collection | DOAJ |
| description | Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics. Both palmitoylation by palmitoyl acyl transferases (PAT) and depalmitoylation by palmitoyl-protein thioesterases (PPT) is regulated in an activity-dependent, localized fashion. Recently, palmitoylation has received attention for its pivotal contribution to various forms of synaptic plasticity, the dynamic modulation of synaptic strength in response to neuronal activity. For instance, palmitoylation and depalmitoylation of the central postsynaptic scaffold protein postsynaptic density-95 (PSD-95) is important for synaptic plasticity. Here, we provide a comprehensive review of studies linking palmitoylation of postsynaptic proteins to synaptic plasticity. |
| first_indexed | 2024-12-10T22:25:50Z |
| format | Article |
| id | doaj.art-f816ed63d5d748668344abf22c1bd3f7 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-10T22:25:50Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-f816ed63d5d748668344abf22c1bd3f72022-12-22T01:31:12ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992019-01-011210.3389/fnmol.2019.00008433553Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic PlasticityLucas Matt0Karam Kim1Dhrubajyoti Chowdhury2Johannes W. Hell3Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, GermanyDepartment of Pharmacology, University of California, Davis, Davis, CA, United StatesDepartment of Pharmacology, University of California, Davis, Davis, CA, United StatesDepartment of Pharmacology, University of California, Davis, Davis, CA, United StatesMany postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics. Both palmitoylation by palmitoyl acyl transferases (PAT) and depalmitoylation by palmitoyl-protein thioesterases (PPT) is regulated in an activity-dependent, localized fashion. Recently, palmitoylation has received attention for its pivotal contribution to various forms of synaptic plasticity, the dynamic modulation of synaptic strength in response to neuronal activity. For instance, palmitoylation and depalmitoylation of the central postsynaptic scaffold protein postsynaptic density-95 (PSD-95) is important for synaptic plasticity. Here, we provide a comprehensive review of studies linking palmitoylation of postsynaptic proteins to synaptic plasticity.https://www.frontiersin.org/article/10.3389/fnmol.2019.00008/fullAMPARNMDARLTPLTDhomeostatic plasticityPSD-95 |
| spellingShingle | Lucas Matt Karam Kim Dhrubajyoti Chowdhury Johannes W. Hell Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity Frontiers in Molecular Neuroscience AMPAR NMDAR LTP LTD homeostatic plasticity PSD-95 |
| title | Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity |
| title_full | Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity |
| title_fullStr | Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity |
| title_full_unstemmed | Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity |
| title_short | Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity |
| title_sort | role of palmitoylation of postsynaptic proteins in promoting synaptic plasticity |
| topic | AMPAR NMDAR LTP LTD homeostatic plasticity PSD-95 |
| url | https://www.frontiersin.org/article/10.3389/fnmol.2019.00008/full |
| work_keys_str_mv | AT lucasmatt roleofpalmitoylationofpostsynapticproteinsinpromotingsynapticplasticity AT karamkim roleofpalmitoylationofpostsynapticproteinsinpromotingsynapticplasticity AT dhrubajyotichowdhury roleofpalmitoylationofpostsynapticproteinsinpromotingsynapticplasticity AT johanneswhell roleofpalmitoylationofpostsynapticproteinsinpromotingsynapticplasticity |