Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection
Neurodegenerative diseases, particularly Parkinson’s and Alzheimer’s, have common features: protein accumulation, cell death with mitochondrial involvement and oxidative stress. Patients are treated to cure the symptoms, but the treatments do not target the causes; so, the disease is not stopped. It...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/7/2501 |
| _version_ | 1797571499631050752 |
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| author | Thomas Nury Gérard Lizard Anne Vejux |
| author_facet | Thomas Nury Gérard Lizard Anne Vejux |
| author_sort | Thomas Nury |
| collection | DOAJ |
| description | Neurodegenerative diseases, particularly Parkinson’s and Alzheimer’s, have common features: protein accumulation, cell death with mitochondrial involvement and oxidative stress. Patients are treated to cure the symptoms, but the treatments do not target the causes; so, the disease is not stopped. It is interesting to look at the side of nutrition which could help prevent the first signs of the disease or slow its progression in addition to existing therapeutic strategies. Lipids, whether in the form of vegetable or animal oils or in the form of fatty acids, could be incorporated into diets with the aim of preventing neurodegenerative diseases. These different lipids can inhibit the cytotoxicity induced during the pathology, whether at the level of mitochondria, oxidative stress or apoptosis and inflammation. The conclusions of the various studies cited are oriented towards the preventive use of oils or fatty acids. The future of these lipids that can be used in therapy/prevention will undoubtedly involve a better delivery to the body and to the brain by utilizing lipid encapsulation. |
| first_indexed | 2024-03-10T20:41:33Z |
| format | Article |
| id | doaj.art-f818f4b0454045ec910cc773090b1280 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:41:33Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f818f4b0454045ec910cc773090b12802023-11-19T20:41:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01217250110.3390/ijms21072501Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and CytoprotectionThomas Nury0Gérard Lizard1Anne Vejux2Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA 7270, Team Bio-peroxIL, Université de Bourgogne Franche-Comté /Inserm, 21000 Dijon, FranceBiochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA 7270, Team Bio-peroxIL, Université de Bourgogne Franche-Comté /Inserm, 21000 Dijon, FranceBiochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA 7270, Team Bio-peroxIL, Université de Bourgogne Franche-Comté /Inserm, 21000 Dijon, FranceNeurodegenerative diseases, particularly Parkinson’s and Alzheimer’s, have common features: protein accumulation, cell death with mitochondrial involvement and oxidative stress. Patients are treated to cure the symptoms, but the treatments do not target the causes; so, the disease is not stopped. It is interesting to look at the side of nutrition which could help prevent the first signs of the disease or slow its progression in addition to existing therapeutic strategies. Lipids, whether in the form of vegetable or animal oils or in the form of fatty acids, could be incorporated into diets with the aim of preventing neurodegenerative diseases. These different lipids can inhibit the cytotoxicity induced during the pathology, whether at the level of mitochondria, oxidative stress or apoptosis and inflammation. The conclusions of the various studies cited are oriented towards the preventive use of oils or fatty acids. The future of these lipids that can be used in therapy/prevention will undoubtedly involve a better delivery to the body and to the brain by utilizing lipid encapsulation.https://www.mdpi.com/1422-0067/21/7/2501lipids nutrientsapoptosisoxidative stressmitochondriasynucleinamyloid |
| spellingShingle | Thomas Nury Gérard Lizard Anne Vejux Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection International Journal of Molecular Sciences lipids nutrients apoptosis oxidative stress mitochondria synuclein amyloid |
| title | Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection |
| title_full | Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection |
| title_fullStr | Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection |
| title_full_unstemmed | Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection |
| title_short | Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection |
| title_sort | lipids nutrients in parkinson and alzheimer s diseases cell death and cytoprotection |
| topic | lipids nutrients apoptosis oxidative stress mitochondria synuclein amyloid |
| url | https://www.mdpi.com/1422-0067/21/7/2501 |
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