Matching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients—a randomized prospective trial
Abstract Background Accommodating a patient’s treatment preference has been reported to promote greater responsiveness and better clinical outcomes. The effect of administration route preference (ARP) on the individual analgesic response has not been extensively examined to date. This study aimed to...
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13018-020-01594-w |
| _version_ | 1828138766385020928 |
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| author | Adi Shani Michal Granot Gleb Mochalov Bennidor Raviv Nimrod Rahamimov |
| author_facet | Adi Shani Michal Granot Gleb Mochalov Bennidor Raviv Nimrod Rahamimov |
| author_sort | Adi Shani |
| collection | DOAJ |
| description | Abstract Background Accommodating a patient’s treatment preference has been reported to promote greater responsiveness and better clinical outcomes. The effect of administration route preference (ARP) on the individual analgesic response has not been extensively examined to date. This study aimed to investigate whether ARP-matched treatment, i.e., individualized intramuscular (IM) or oral (PO) analgesic administration according to patient choice, would increase the analgesic effect. Methods In this prospective randomized study, we collected 38 patients with acute low back pain (aLBP) presenting at the emergency room of the Galilee Medical Center (Naharia, Israel) and asked them to report their ARP for analgesics. Regardless of their reported preference, they received either PO or IM diclofenac according to the treating physician’s preference. Pain intensity was self-reported using the numeric pain score (NPS) before and during the first hour after drug administration. Results Both groups receiving PO or IM administration reported similar initial pain on admission, (NPS 8.63 ± 1.5 and 8.74 ± 1.6, respectively) and the same magnitude of pain reduction. However, patients who received the drug in their desired route (oral or injection) had a significantly greater reduction in pain levels (4.05 ± 2.8) as compared with patients who received the undesired route (2.08 ± 1.8), p < 0.05. Conclusions These findings support the hypothesis that individualized ARP-matched treatment in aLBP improves therapeutic outcomes, although further studies with larger cohorts are needed. |
| first_indexed | 2024-04-11T18:41:26Z |
| format | Article |
| id | doaj.art-f8191d6cfe3844a9b7256038ebcbe28f |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T18:41:26Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-f8191d6cfe3844a9b7256038ebcbe28f2022-12-22T04:08:59ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-02-011511810.1186/s13018-020-01594-wMatching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients—a randomized prospective trialAdi Shani0Michal Granot1Gleb Mochalov2Bennidor Raviv3Nimrod Rahamimov4Spine Surgery Unit, Galilee Medical CenterDept. of Nursing, Faculty of Social Welfare and Health Sciences, University of HaifaDept. of Orthopedics B, Galilee Medical CenterBar-Ilan University Medical SchoolBar-Ilan University Medical SchoolAbstract Background Accommodating a patient’s treatment preference has been reported to promote greater responsiveness and better clinical outcomes. The effect of administration route preference (ARP) on the individual analgesic response has not been extensively examined to date. This study aimed to investigate whether ARP-matched treatment, i.e., individualized intramuscular (IM) or oral (PO) analgesic administration according to patient choice, would increase the analgesic effect. Methods In this prospective randomized study, we collected 38 patients with acute low back pain (aLBP) presenting at the emergency room of the Galilee Medical Center (Naharia, Israel) and asked them to report their ARP for analgesics. Regardless of their reported preference, they received either PO or IM diclofenac according to the treating physician’s preference. Pain intensity was self-reported using the numeric pain score (NPS) before and during the first hour after drug administration. Results Both groups receiving PO or IM administration reported similar initial pain on admission, (NPS 8.63 ± 1.5 and 8.74 ± 1.6, respectively) and the same magnitude of pain reduction. However, patients who received the drug in their desired route (oral or injection) had a significantly greater reduction in pain levels (4.05 ± 2.8) as compared with patients who received the undesired route (2.08 ± 1.8), p < 0.05. Conclusions These findings support the hypothesis that individualized ARP-matched treatment in aLBP improves therapeutic outcomes, although further studies with larger cohorts are needed.http://link.springer.com/article/10.1186/s13018-020-01594-wBack painPlaceboPatient preferenceIndividualized medicineAdministration route preference |
| spellingShingle | Adi Shani Michal Granot Gleb Mochalov Bennidor Raviv Nimrod Rahamimov Matching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients—a randomized prospective trial Journal of Orthopaedic Surgery and Research Back pain Placebo Patient preference Individualized medicine Administration route preference |
| title | Matching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients—a randomized prospective trial |
| title_full | Matching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients—a randomized prospective trial |
| title_fullStr | Matching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients—a randomized prospective trial |
| title_full_unstemmed | Matching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients—a randomized prospective trial |
| title_short | Matching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients—a randomized prospective trial |
| title_sort | matching actual treatment with patient administration route preference improves analgesic response among acute low back pain patients a randomized prospective trial |
| topic | Back pain Placebo Patient preference Individualized medicine Administration route preference |
| url | http://link.springer.com/article/10.1186/s13018-020-01594-w |
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