Head and neck cutaneous melanoma: 5-year survival analysis in a Serbian university center
Abstract Background Head and neck melanoma (HNM) is specific from the anatomical and etiopathogenetic aspects. In addition to morphopathological parameters, rich vascularization and lymphatic drainage of the head and neck affect the occurrence of lymphogenic and hematogenous metastases, as well as t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-020-02091-4 |
| _version_ | 1818389491893665792 |
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| author | Aleksandar Višnjić Predrag Kovačević Asen Veličkov Mariola Stojanović Stefan Mladenović |
| author_facet | Aleksandar Višnjić Predrag Kovačević Asen Veličkov Mariola Stojanović Stefan Mladenović |
| author_sort | Aleksandar Višnjić |
| collection | DOAJ |
| description | Abstract Background Head and neck melanoma (HNM) is specific from the anatomical and etiopathogenetic aspects. In addition to morphopathological parameters, rich vascularization and lymphatic drainage of the head and neck affect the occurrence of lymphogenic and hematogenous metastases, as well as the metastases on both sides of the neck. Methods A retrospective cross-sectional study included cutaneous melanoma patients who underwent surgery at a clinical center over a 10-year period. The clinical follow-up was at least 60 months. The Kaplan-Meier method was used for the survival analysis. The predictor effect of certain independent variables on a given dichotomous dependent variable (survival) was measured by the Cox regression analysis. Results The analysis of demographic and clinical characteristics of 116 patients with HNM revealed that there was no statistically significant difference in age and gender in the total sample. Thirty-three (28.45%) patients were already in stage III or IV of the disease at the first examination, which affected the overall survival rate. The overall 5-year survival was 30.2%. No statistically significant difference in 5-year survival was found in relation to age and location. The period without melanoma progression decreased progressively in the advanced stage. Forty-nine patients (42%) underwent surgery for lymphogenic metastases in the parotid region and/or neck during the follow-up. Conclusions Patients with HNM included in this study frequently presented an advanced stage of the disease at the first examination, which is reflected in a low rate of 5-year survival. Early diagnosis and adequate primary treatment can ensure longer survival. |
| first_indexed | 2024-12-14T04:42:35Z |
| format | Article |
| id | doaj.art-f8198fe9c1cc44ccb2d92c1d79b6146a |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-14T04:42:35Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-f8198fe9c1cc44ccb2d92c1d79b6146a2022-12-21T23:16:46ZengBMCWorld Journal of Surgical Oncology1477-78192020-11-011811810.1186/s12957-020-02091-4Head and neck cutaneous melanoma: 5-year survival analysis in a Serbian university centerAleksandar Višnjić0Predrag Kovačević1Asen Veličkov2Mariola Stojanović3Stefan Mladenović4Department of Social Medicine, Faculty of Medicine, University of NišDepartment of Surgery, Faculty of Medicine, University of NišTrauma and Reconstructive Surgery, Orthopedics, Kreisklinik RothInstitute of Public Health of NišClinic for Plastic and Reconstructive Surgery, Clinical Centre of NišAbstract Background Head and neck melanoma (HNM) is specific from the anatomical and etiopathogenetic aspects. In addition to morphopathological parameters, rich vascularization and lymphatic drainage of the head and neck affect the occurrence of lymphogenic and hematogenous metastases, as well as the metastases on both sides of the neck. Methods A retrospective cross-sectional study included cutaneous melanoma patients who underwent surgery at a clinical center over a 10-year period. The clinical follow-up was at least 60 months. The Kaplan-Meier method was used for the survival analysis. The predictor effect of certain independent variables on a given dichotomous dependent variable (survival) was measured by the Cox regression analysis. Results The analysis of demographic and clinical characteristics of 116 patients with HNM revealed that there was no statistically significant difference in age and gender in the total sample. Thirty-three (28.45%) patients were already in stage III or IV of the disease at the first examination, which affected the overall survival rate. The overall 5-year survival was 30.2%. No statistically significant difference in 5-year survival was found in relation to age and location. The period without melanoma progression decreased progressively in the advanced stage. Forty-nine patients (42%) underwent surgery for lymphogenic metastases in the parotid region and/or neck during the follow-up. Conclusions Patients with HNM included in this study frequently presented an advanced stage of the disease at the first examination, which is reflected in a low rate of 5-year survival. Early diagnosis and adequate primary treatment can ensure longer survival.https://doi.org/10.1186/s12957-020-02091-4MelanomaHead and neckSurvivalPredictors |
| spellingShingle | Aleksandar Višnjić Predrag Kovačević Asen Veličkov Mariola Stojanović Stefan Mladenović Head and neck cutaneous melanoma: 5-year survival analysis in a Serbian university center World Journal of Surgical Oncology Melanoma Head and neck Survival Predictors |
| title | Head and neck cutaneous melanoma: 5-year survival analysis in a Serbian university center |
| title_full | Head and neck cutaneous melanoma: 5-year survival analysis in a Serbian university center |
| title_fullStr | Head and neck cutaneous melanoma: 5-year survival analysis in a Serbian university center |
| title_full_unstemmed | Head and neck cutaneous melanoma: 5-year survival analysis in a Serbian university center |
| title_short | Head and neck cutaneous melanoma: 5-year survival analysis in a Serbian university center |
| title_sort | head and neck cutaneous melanoma 5 year survival analysis in a serbian university center |
| topic | Melanoma Head and neck Survival Predictors |
| url | https://doi.org/10.1186/s12957-020-02091-4 |
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