Extraintestinal <i>Clostridioides difficile</i> Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature
Extraintestinal manifestations of <i>Clostridioides difficile</i> infections (CDIs) are very uncommon, and according to the literature, poor outcomes and a high mortality have been observed among affected individuals. The objective of this study was to investigate the incidence rate of e...
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MDPI AG
2020-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/1/16 |
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| author | Edit Urbán Gabriella Terhes Márió Gajdács |
| author_facet | Edit Urbán Gabriella Terhes Márió Gajdács |
| author_sort | Edit Urbán |
| collection | DOAJ |
| description | Extraintestinal manifestations of <i>Clostridioides difficile</i> infections (CDIs) are very uncommon, and according to the literature, poor outcomes and a high mortality have been observed among affected individuals. The objective of this study was to investigate the incidence rate of extraintestinal infections caused by <i>C. difficile</i> (ECD) in a tertiary-care university hospital in Hungary. During a 10-year study period, the microbiology laboratory isolated 4129 individual strains of <i>C. difficile</i>; among these, the majority were either from diarrheal fecal samples or from colonic material and only <i>n</i> = 24 (0.58%) were from extraintestinal sources. The 24 extraintestinal <i>C. difficile</i> isolates were recovered from 22 patients (female-to-male ratio: 1, average age: 55.4 years). The isolates in <i>n</i> = 8 patients were obtained from abdominal infections, e.g., appendicitis, rectal abscess or Crohn’s disease. These extraintestinal cases occurred without concomitant diarrhea. In all, but two cases <i>C. difficile</i> was obtained as a part of a polymicrobial flora. Our isolates were frequently toxigenic and mostly belonged to PCR ribotype 027. Resistance to metronidazole, vancomycin, clindamycin and rifampin were 0%, 0%, 20.5% and 9.7%, respectively. The increasing amount of reports of <i>C. difficile</i> extraintestinal infections should be noted, as these infections are characterized by a poor outcome and high mortality rate. |
| first_indexed | 2024-04-13T08:10:53Z |
| format | Article |
| id | doaj.art-f81c5d2ee9264487b2fecf9a946ff805 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-04-13T08:10:53Z |
| publishDate | 2020-01-01 |
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| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-f81c5d2ee9264487b2fecf9a946ff8052022-12-22T02:55:00ZengMDPI AGAntibiotics2079-63822020-01-01911610.3390/antibiotics9010016antibiotics9010016Extraintestinal <i>Clostridioides difficile</i> Infections: Epidemiology in a University Hospital in Hungary and Review of the LiteratureEdit Urbán0Gabriella Terhes1Márió Gajdács2Department of Public Health, Faculty of Medicine, University of Szeged, Dóm tér 10., 6720 Szeged, HungaryInstitute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Semmelweis utca 6., 6725 Szeged, HungaryDepartment of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6., 6720 Szeged, HungaryExtraintestinal manifestations of <i>Clostridioides difficile</i> infections (CDIs) are very uncommon, and according to the literature, poor outcomes and a high mortality have been observed among affected individuals. The objective of this study was to investigate the incidence rate of extraintestinal infections caused by <i>C. difficile</i> (ECD) in a tertiary-care university hospital in Hungary. During a 10-year study period, the microbiology laboratory isolated 4129 individual strains of <i>C. difficile</i>; among these, the majority were either from diarrheal fecal samples or from colonic material and only <i>n</i> = 24 (0.58%) were from extraintestinal sources. The 24 extraintestinal <i>C. difficile</i> isolates were recovered from 22 patients (female-to-male ratio: 1, average age: 55.4 years). The isolates in <i>n</i> = 8 patients were obtained from abdominal infections, e.g., appendicitis, rectal abscess or Crohn’s disease. These extraintestinal cases occurred without concomitant diarrhea. In all, but two cases <i>C. difficile</i> was obtained as a part of a polymicrobial flora. Our isolates were frequently toxigenic and mostly belonged to PCR ribotype 027. Resistance to metronidazole, vancomycin, clindamycin and rifampin were 0%, 0%, 20.5% and 9.7%, respectively. The increasing amount of reports of <i>C. difficile</i> extraintestinal infections should be noted, as these infections are characterized by a poor outcome and high mortality rate.https://www.mdpi.com/2079-6382/9/1/16<i>clostridioides difficile</i>extraintestinalinfectionbacteremiaintraoperative infectionsabscesswound infectionepidemiologyanaerobes |
| spellingShingle | Edit Urbán Gabriella Terhes Márió Gajdács Extraintestinal <i>Clostridioides difficile</i> Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature Antibiotics <i>clostridioides difficile</i> extraintestinal infection bacteremia intraoperative infections abscess wound infection epidemiology anaerobes |
| title | Extraintestinal <i>Clostridioides difficile</i> Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature |
| title_full | Extraintestinal <i>Clostridioides difficile</i> Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature |
| title_fullStr | Extraintestinal <i>Clostridioides difficile</i> Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature |
| title_full_unstemmed | Extraintestinal <i>Clostridioides difficile</i> Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature |
| title_short | Extraintestinal <i>Clostridioides difficile</i> Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature |
| title_sort | extraintestinal i clostridioides difficile i infections epidemiology in a university hospital in hungary and review of the literature |
| topic | <i>clostridioides difficile</i> extraintestinal infection bacteremia intraoperative infections abscess wound infection epidemiology anaerobes |
| url | https://www.mdpi.com/2079-6382/9/1/16 |
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