Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry.
<h4>Objective</h4>The complex link between nutritional status, protein and lipid synthesis, and immunity plays an important prognostic role in patients with heart failure. However, the association between appetite loss at discharge and long-term outcome remains unclear.<h4>Methods&...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0267327 |
| _version_ | 1811296602349895680 |
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| author | Erika Yamamoto Takao Kato Hidenori Yaku Takeshi Morimoto Yasutaka Inuzuka Yodo Tamaki Neiko Ozasa Yusuke Yoshikawa Takeshi Kitai Ryoji Taniguchi Moritake Iguchi Masashi Kato Mamoru Takahashi Toshikazu Jinnai Tomoyuki Ikeda Kazuya Nagao Takafumi Kawai Akihiro Komasa Ryusuke Nishikawa Yuichi Kawase Takashi Morinaga Mitsunori Kawato Yuta Seko Masayuki Shiba Mamoru Toyofuku Yutaka Furukawa Yoshihisa Nakagawa Kenji Ando Kazushige Kadota Satoshi Shizuta Koh Ono Yukihito Sato Koichiro Kuwahara Takeshi Kimura |
| author_facet | Erika Yamamoto Takao Kato Hidenori Yaku Takeshi Morimoto Yasutaka Inuzuka Yodo Tamaki Neiko Ozasa Yusuke Yoshikawa Takeshi Kitai Ryoji Taniguchi Moritake Iguchi Masashi Kato Mamoru Takahashi Toshikazu Jinnai Tomoyuki Ikeda Kazuya Nagao Takafumi Kawai Akihiro Komasa Ryusuke Nishikawa Yuichi Kawase Takashi Morinaga Mitsunori Kawato Yuta Seko Masayuki Shiba Mamoru Toyofuku Yutaka Furukawa Yoshihisa Nakagawa Kenji Ando Kazushige Kadota Satoshi Shizuta Koh Ono Yukihito Sato Koichiro Kuwahara Takeshi Kimura |
| author_sort | Erika Yamamoto |
| collection | DOAJ |
| description | <h4>Objective</h4>The complex link between nutritional status, protein and lipid synthesis, and immunity plays an important prognostic role in patients with heart failure. However, the association between appetite loss at discharge and long-term outcome remains unclear.<h4>Methods</h4>The Kyoto Congestive Heart Failure registry is a prospective cohort study that enrolled consecutive patients hospitalized for acute decompensated heart failure (ADHF) in Japan. We assessed 3528 patients alive at discharge, and for whom appetite and follow-up data were available. We compared one-year clinical outcomes in patients with and without appetite loss at discharge.<h4>Results</h4>In the multivariable logistic regression analysis using 19 clinical and laboratory factors with P value < 0.1 by univariate analysis, BMI < 22 kg/m2 (odds ratio (OR): 1.57, 95% confidence interval (CI): 1.11-2.24, P = 0.01), CRP >1.0mg/dL (OR: 1.49, 95%CI: 1.04-2.14, P = 0.03), and presence of edema at discharge (OR: 4.30, 95%CI: 2.99-6.22, P<0.001) were associated with an increased risk of appetite loss at discharge, whereas ambulatory status (OR: 0.57, 95%CI: 0.39-0.83, P = 0.004) and the use of ACE-I/ARB (OR: 0.70, 95% CI: 0.50-0.98, P = 0.04) were related to a decreased risk in the presence of appetite loss. The cumulative 1-year incidence of all-cause death (primary outcome measure) was significantly higher in patients with appetite loss than in those without appetite loss (31.0% vs. 15.0%, P<0.001). The excess adjusted risk of appetite loss relative to no appetite loss remained significant for all-cause death (hazard ratio (HR): 1.63, 95%CI: 1.29-2.07, P<0.001).<h4>Conclusions</h4>Loss of appetite at discharge was associated with worse 1-year mortality in patients with ADHF. Appetite is a simple, reliable, and useful subjective marker for risk stratification of patients with ADHF. |
| first_indexed | 2024-04-13T05:50:55Z |
| format | Article |
| id | doaj.art-f81cd6183ef54d918edd6ada6125798f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T05:50:55Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f81cd6183ef54d918edd6ada6125798f2022-12-22T02:59:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01175e026732710.1371/journal.pone.0267327Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry.Erika YamamotoTakao KatoHidenori YakuTakeshi MorimotoYasutaka InuzukaYodo TamakiNeiko OzasaYusuke YoshikawaTakeshi KitaiRyoji TaniguchiMoritake IguchiMasashi KatoMamoru TakahashiToshikazu JinnaiTomoyuki IkedaKazuya NagaoTakafumi KawaiAkihiro KomasaRyusuke NishikawaYuichi KawaseTakashi MorinagaMitsunori KawatoYuta SekoMasayuki ShibaMamoru ToyofukuYutaka FurukawaYoshihisa NakagawaKenji AndoKazushige KadotaSatoshi ShizutaKoh OnoYukihito SatoKoichiro KuwaharaTakeshi Kimura<h4>Objective</h4>The complex link between nutritional status, protein and lipid synthesis, and immunity plays an important prognostic role in patients with heart failure. However, the association between appetite loss at discharge and long-term outcome remains unclear.<h4>Methods</h4>The Kyoto Congestive Heart Failure registry is a prospective cohort study that enrolled consecutive patients hospitalized for acute decompensated heart failure (ADHF) in Japan. We assessed 3528 patients alive at discharge, and for whom appetite and follow-up data were available. We compared one-year clinical outcomes in patients with and without appetite loss at discharge.<h4>Results</h4>In the multivariable logistic regression analysis using 19 clinical and laboratory factors with P value < 0.1 by univariate analysis, BMI < 22 kg/m2 (odds ratio (OR): 1.57, 95% confidence interval (CI): 1.11-2.24, P = 0.01), CRP >1.0mg/dL (OR: 1.49, 95%CI: 1.04-2.14, P = 0.03), and presence of edema at discharge (OR: 4.30, 95%CI: 2.99-6.22, P<0.001) were associated with an increased risk of appetite loss at discharge, whereas ambulatory status (OR: 0.57, 95%CI: 0.39-0.83, P = 0.004) and the use of ACE-I/ARB (OR: 0.70, 95% CI: 0.50-0.98, P = 0.04) were related to a decreased risk in the presence of appetite loss. The cumulative 1-year incidence of all-cause death (primary outcome measure) was significantly higher in patients with appetite loss than in those without appetite loss (31.0% vs. 15.0%, P<0.001). The excess adjusted risk of appetite loss relative to no appetite loss remained significant for all-cause death (hazard ratio (HR): 1.63, 95%CI: 1.29-2.07, P<0.001).<h4>Conclusions</h4>Loss of appetite at discharge was associated with worse 1-year mortality in patients with ADHF. Appetite is a simple, reliable, and useful subjective marker for risk stratification of patients with ADHF.https://doi.org/10.1371/journal.pone.0267327 |
| spellingShingle | Erika Yamamoto Takao Kato Hidenori Yaku Takeshi Morimoto Yasutaka Inuzuka Yodo Tamaki Neiko Ozasa Yusuke Yoshikawa Takeshi Kitai Ryoji Taniguchi Moritake Iguchi Masashi Kato Mamoru Takahashi Toshikazu Jinnai Tomoyuki Ikeda Kazuya Nagao Takafumi Kawai Akihiro Komasa Ryusuke Nishikawa Yuichi Kawase Takashi Morinaga Mitsunori Kawato Yuta Seko Masayuki Shiba Mamoru Toyofuku Yutaka Furukawa Yoshihisa Nakagawa Kenji Ando Kazushige Kadota Satoshi Shizuta Koh Ono Yukihito Sato Koichiro Kuwahara Takeshi Kimura Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry. PLoS ONE |
| title | Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry. |
| title_full | Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry. |
| title_fullStr | Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry. |
| title_full_unstemmed | Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry. |
| title_short | Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry. |
| title_sort | appetite loss at discharge from acute decompensated heart failure observation from kchf registry |
| url | https://doi.org/10.1371/journal.pone.0267327 |
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