Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests
Abstract Background The aim of this study is to investigate the alterations of choroidal thickness (CT) in juvenile systemic lupus erythematosus (JSLE) using enhanced depth imaging optical coherence tomography (EDI-OCT). We also aimed to assess whether CT parameters correlated with systemic health s...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-023-02906-4 |
| _version_ | 1797846053730385920 |
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| author | Li Ru Jinping Xu Zhongjing Lin Lanfang Cao Lin Zhang |
| author_facet | Li Ru Jinping Xu Zhongjing Lin Lanfang Cao Lin Zhang |
| author_sort | Li Ru |
| collection | DOAJ |
| description | Abstract Background The aim of this study is to investigate the alterations of choroidal thickness (CT) in juvenile systemic lupus erythematosus (JSLE) using enhanced depth imaging optical coherence tomography (EDI-OCT). We also aimed to assess whether CT parameters correlated with systemic health status in JSLE patients. Methods JSLE patients and age- and sex-matched healthy subjects were recruited. A detailed ophthalmological examination was applied to all participants. CT measurements were acquired in the macular region using EDI-OCT. Moreover, a spectrum of laboratory tests was examined to evaluate the systemic conditions, and the Th1/Th2/Th17/Treg cytokine profiles in the peripheral blood were also analyzed in JSLE group. Results A total of 45 JSLE patients with no visual impairment and 50 healthy individuals were enrolled in the study. CT values in the macular region were decreased in JSLE patients when compared with healthy controls, even adjusting for age, axial length and refraction. There were no significant correlations between CT and cumulative dose of hydroxychloroquine or duration of hydroxychloroquine use (all P > 0.05). The average macular, temporal and subfoveal CT in JSLE group was negatively correlated with IL-6 and IL-10 (all P < 0.05), but had no significant correlations with other laboratory results (all P > 0.05). Conclusions JSLE patients without ocular involvement may have significant variations in choroidal thickness at the macular area. Choroidal alterations might be associated with the systemic cytokine profiles in JSLE. |
| first_indexed | 2024-04-09T17:49:53Z |
| format | Article |
| id | doaj.art-f81e6c1a21a54e1eb16c9d9a430125dc |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-09T17:49:53Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-f81e6c1a21a54e1eb16c9d9a430125dc2023-04-16T11:09:37ZengBMCBMC Ophthalmology1471-24152023-04-0123111010.1186/s12886-023-02906-4Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory testsLi Ru0Jinping Xu1Zhongjing Lin2Lanfang Cao3Lin Zhang4Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Pediatrics, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Pediatrics, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityAbstract Background The aim of this study is to investigate the alterations of choroidal thickness (CT) in juvenile systemic lupus erythematosus (JSLE) using enhanced depth imaging optical coherence tomography (EDI-OCT). We also aimed to assess whether CT parameters correlated with systemic health status in JSLE patients. Methods JSLE patients and age- and sex-matched healthy subjects were recruited. A detailed ophthalmological examination was applied to all participants. CT measurements were acquired in the macular region using EDI-OCT. Moreover, a spectrum of laboratory tests was examined to evaluate the systemic conditions, and the Th1/Th2/Th17/Treg cytokine profiles in the peripheral blood were also analyzed in JSLE group. Results A total of 45 JSLE patients with no visual impairment and 50 healthy individuals were enrolled in the study. CT values in the macular region were decreased in JSLE patients when compared with healthy controls, even adjusting for age, axial length and refraction. There were no significant correlations between CT and cumulative dose of hydroxychloroquine or duration of hydroxychloroquine use (all P > 0.05). The average macular, temporal and subfoveal CT in JSLE group was negatively correlated with IL-6 and IL-10 (all P < 0.05), but had no significant correlations with other laboratory results (all P > 0.05). Conclusions JSLE patients without ocular involvement may have significant variations in choroidal thickness at the macular area. Choroidal alterations might be associated with the systemic cytokine profiles in JSLE.https://doi.org/10.1186/s12886-023-02906-4Choroidal thicknessSystemic lupus erythematosusOptical coherence tomographyCytokine |
| spellingShingle | Li Ru Jinping Xu Zhongjing Lin Lanfang Cao Lin Zhang Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests BMC Ophthalmology Choroidal thickness Systemic lupus erythematosus Optical coherence tomography Cytokine |
| title | Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests |
| title_full | Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests |
| title_fullStr | Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests |
| title_full_unstemmed | Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests |
| title_short | Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests |
| title_sort | analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests |
| topic | Choroidal thickness Systemic lupus erythematosus Optical coherence tomography Cytokine |
| url | https://doi.org/10.1186/s12886-023-02906-4 |
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