Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound Stimulations
Abstract Repetitive stimulation procedures are used in neuromodulation techniques to induce persistent excitatory or inhibitory brain activity. The directivity of modulation is empirically regulated by modifying the stimulation length, interval, and strength. However, bidirectional neuronal modulati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202302404 |
| _version_ | 1827382804927741952 |
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| author | Taewon Choi Minseok Koo Jaesoon Joo Taekyung Kim Young‐Min Shon Jinhyoung Park |
| author_facet | Taewon Choi Minseok Koo Jaesoon Joo Taekyung Kim Young‐Min Shon Jinhyoung Park |
| author_sort | Taewon Choi |
| collection | DOAJ |
| description | Abstract Repetitive stimulation procedures are used in neuromodulation techniques to induce persistent excitatory or inhibitory brain activity. The directivity of modulation is empirically regulated by modifying the stimulation length, interval, and strength. However, bidirectional neuronal modulations using ultrasound stimulations are rarely reported. This study presents bidirectional control of epileptiform activities with repetitive transcranial‐focused ultrasound stimulations in a rat model of drug‐induced acute epilepsy. It is found that repeated transmission of elongated (40 s), ultra‐low pressure (0.25 MPa) ultrasound can fully suppress epileptic activities in electro‐encephalography and cerebral blood volume measurements, while the change in bursting intervals from 40 to 20 s worsens epileptic activities even with the same burst length. Furthermore, the suppression induced by 40 s long bursts is transformed to excitatory states by a subsequent transmission. Bidirectional modulation of epileptic seizures with repeated ultrasound stimulation is achieved by regulating the changes in glutamate and γ‐Aminobutyric acid levels, as confirmed by measurements of expressed c‐Fos and GAD65 and multitemporal analysis of neurotransmitters in the interstitial fluid obtained via microdialysis. |
| first_indexed | 2024-03-08T14:26:41Z |
| format | Article |
| id | doaj.art-f82015cd8fad4d099e750a1bbc4d002f |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-08T14:26:41Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-f82015cd8fad4d099e750a1bbc4d002f2024-01-13T04:23:06ZengWileyAdvanced Science2198-38442024-01-01112n/an/a10.1002/advs.202302404Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound StimulationsTaewon Choi0Minseok Koo1Jaesoon Joo2Taekyung Kim3Young‐Min Shon4Jinhyoung Park5Department of Intelligent Precision Healthcare Convergence Sungkyunkwan University Suwon 16419 South KoreaDepartment of Intelligent Precision Healthcare Convergence Sungkyunkwan University Suwon 16419 South KoreaDepartment of Health Sciences and Technology Samsung Advanced Institute for Health Science and Technology Sungkyunkwan University Seoul 06351 South KoreaBiomedical Engineering Research Center Samsung Medical Center Seoul 06351 South KoreaDepartment of Health Sciences and Technology Samsung Advanced Institute for Health Science and Technology Sungkyunkwan University Seoul 06351 South KoreaDepartment of Intelligent Precision Healthcare Convergence Sungkyunkwan University Suwon 16419 South KoreaAbstract Repetitive stimulation procedures are used in neuromodulation techniques to induce persistent excitatory or inhibitory brain activity. The directivity of modulation is empirically regulated by modifying the stimulation length, interval, and strength. However, bidirectional neuronal modulations using ultrasound stimulations are rarely reported. This study presents bidirectional control of epileptiform activities with repetitive transcranial‐focused ultrasound stimulations in a rat model of drug‐induced acute epilepsy. It is found that repeated transmission of elongated (40 s), ultra‐low pressure (0.25 MPa) ultrasound can fully suppress epileptic activities in electro‐encephalography and cerebral blood volume measurements, while the change in bursting intervals from 40 to 20 s worsens epileptic activities even with the same burst length. Furthermore, the suppression induced by 40 s long bursts is transformed to excitatory states by a subsequent transmission. Bidirectional modulation of epileptic seizures with repeated ultrasound stimulation is achieved by regulating the changes in glutamate and γ‐Aminobutyric acid levels, as confirmed by measurements of expressed c‐Fos and GAD65 and multitemporal analysis of neurotransmitters in the interstitial fluid obtained via microdialysis.https://doi.org/10.1002/advs.202302404antiepileptic treatmentbidirectional neuronal controlepileptiform activitytranscranial focused ultrasound |
| spellingShingle | Taewon Choi Minseok Koo Jaesoon Joo Taekyung Kim Young‐Min Shon Jinhyoung Park Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound Stimulations Advanced Science antiepileptic treatment bidirectional neuronal control epileptiform activity transcranial focused ultrasound |
| title | Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound Stimulations |
| title_full | Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound Stimulations |
| title_fullStr | Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound Stimulations |
| title_full_unstemmed | Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound Stimulations |
| title_short | Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound Stimulations |
| title_sort | bidirectional neuronal control of epileptiform activity by repetitive transcranial focused ultrasound stimulations |
| topic | antiepileptic treatment bidirectional neuronal control epileptiform activity transcranial focused ultrasound |
| url | https://doi.org/10.1002/advs.202302404 |
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