HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements.
For the past decade protein acetylation has been shown to be a crucial post-transcriptional modification involved in the regulation of protein functions. Histone acetyltransferases (HATs) mediate acetylation of histones which results in the nucleosomal relaxation associated with gene expression. The...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00042/full |
| _version_ | 1818390151706968064 |
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| author | Michal eMielcarek Daniel eZielonka Alisia eCarnemolla Jerzy T Marcinkowski Fabien eGuidez |
| author_facet | Michal eMielcarek Daniel eZielonka Alisia eCarnemolla Jerzy T Marcinkowski Fabien eGuidez |
| author_sort | Michal eMielcarek |
| collection | DOAJ |
| description | For the past decade protein acetylation has been shown to be a crucial post-transcriptional modification involved in the regulation of protein functions. Histone acetyltransferases (HATs) mediate acetylation of histones which results in the nucleosomal relaxation associated with gene expression. The reverse reaction, histone deacetylation, is mediated by histone deacetylases (HDACs) leading to chromatin condensation followed by transcriptional repression. HDACs are divided into distinct classes: I, IIa, IIb, III and IV, on the basis of size and sequence homology, as well as formation of distinct repressor complexes. Implications of HDACs in many diseases, such as cancer, heart failure and neurodegeneration, have identified these molecules as unique and attractive therapeutic targets. The emergence of HDAC4 among the members of class IIa family as a major player in synaptic plasticity raises important questions about its functions in the brain. The characterization of HDAC4 specific substrates and molecular partners in the brain will not only provide a better understanding of HDAC4 biological functions but also might help to develop new therapeutic strategies to target numerous malignancies. In this review we highlight and summarize recent achievements in understanding the biological role of HDAC4 in neurodegenerative processes. |
| first_indexed | 2024-12-14T04:53:04Z |
| format | Article |
| id | doaj.art-f82058161b0d4443a2f44025237a7ca4 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-14T04:53:04Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-f82058161b0d4443a2f44025237a7ca42022-12-21T23:16:29ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-02-01910.3389/fncel.2015.00042123082HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements.Michal eMielcarek0Daniel eZielonka1Alisia eCarnemolla2Jerzy T Marcinkowski3Fabien eGuidez4King's College LondonPoznan University of Medical SciencesKing's College LondonPoznan University of Medical SciencesINSERM, Université Paris DiderotFor the past decade protein acetylation has been shown to be a crucial post-transcriptional modification involved in the regulation of protein functions. Histone acetyltransferases (HATs) mediate acetylation of histones which results in the nucleosomal relaxation associated with gene expression. The reverse reaction, histone deacetylation, is mediated by histone deacetylases (HDACs) leading to chromatin condensation followed by transcriptional repression. HDACs are divided into distinct classes: I, IIa, IIb, III and IV, on the basis of size and sequence homology, as well as formation of distinct repressor complexes. Implications of HDACs in many diseases, such as cancer, heart failure and neurodegeneration, have identified these molecules as unique and attractive therapeutic targets. The emergence of HDAC4 among the members of class IIa family as a major player in synaptic plasticity raises important questions about its functions in the brain. The characterization of HDAC4 specific substrates and molecular partners in the brain will not only provide a better understanding of HDAC4 biological functions but also might help to develop new therapeutic strategies to target numerous malignancies. In this review we highlight and summarize recent achievements in understanding the biological role of HDAC4 in neurodegenerative processes.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00042/fullHistone DeacetylasessignallingneurodegenerationHDAC inhibitorsHDAC4therapeutic potential. |
| spellingShingle | Michal eMielcarek Daniel eZielonka Alisia eCarnemolla Jerzy T Marcinkowski Fabien eGuidez HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements. Frontiers in Cellular Neuroscience Histone Deacetylases signalling neurodegeneration HDAC inhibitors HDAC4 therapeutic potential. |
| title | HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements. |
| title_full | HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements. |
| title_fullStr | HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements. |
| title_full_unstemmed | HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements. |
| title_short | HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements. |
| title_sort | hdac4 as a potential therapeutic target in neurodegenerative diseases a summary of recent achievements |
| topic | Histone Deacetylases signalling neurodegeneration HDAC inhibitors HDAC4 therapeutic potential. |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00042/full |
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