HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements.

HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements.

For the past decade protein acetylation has been shown to be a crucial post-transcriptional modification involved in the regulation of protein functions. Histone acetyltransferases (HATs) mediate acetylation of histones which results in the nucleosomal relaxation associated with gene expression. The...

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Bibliographic Details
Main Authors: Michal eMielcarek, Daniel eZielonka, Alisia eCarnemolla, Jerzy T Marcinkowski, Fabien eGuidez
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Histone Deacetylases
signalling
neurodegeneration
HDAC inhibitors
HDAC4
therapeutic potential.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00042/full

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