Clinical predictors of lung function in patients recovering from mild COVID-19
Abstract Background Few studies have assessed lung function in Hispanic subjects recovering from mild COVID-19. Therefore, we examined the prevalence of impaired pulmonary diffusing capacity for carbon monoxide (DLCO) as defined by values below the lower limit of normal (< LLN, < 5th percentil...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-022-02086-9 |
| _version_ | 1811222898197659648 |
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| author | Arturo Cortes-Telles Esperanza Figueroa-Hurtado Diana Lizbeth Ortiz-Farias Gerald Stanley Zavorsky |
| author_facet | Arturo Cortes-Telles Esperanza Figueroa-Hurtado Diana Lizbeth Ortiz-Farias Gerald Stanley Zavorsky |
| author_sort | Arturo Cortes-Telles |
| collection | DOAJ |
| description | Abstract Background Few studies have assessed lung function in Hispanic subjects recovering from mild COVID-19. Therefore, we examined the prevalence of impaired pulmonary diffusing capacity for carbon monoxide (DLCO) as defined by values below the lower limit of normal (< LLN, < 5th percentile) or less than 80% of predicted in Hispanics recovering from mild COVID-19. We also examined the prevalence of a restrictive spirometric pattern as defined by the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) being ≥ LLN with the FVC being < LLN. Finally, we evaluated previous studies to find factors correlated to impaired DLCO post-COVID-19. Methods In this observational study, adult patients (n = 146) with mild COVID-19 were recruited from a long-term follow-up COVID-19 clinic in Yucatan, Mexico, between March and August 2021. Spirometry, DLCO, and self-reported signs/symptoms were recorded 34 ± 4 days after diagnosis. Results At post-evaluation, 20% and 30% of patients recovering from COVID-19 were classified as having a restrictive spirometric pattern and impaired DLCO, respectively; 13% had both. The most prevalent reported symptoms were fatigue (73%), a persistent cough (43%), shortness of breath (42%) and a blocked/runny nose (36%). Increased age and a restrictive spirometric pattern increased the probability of having an impaired DLCO while having a blocked nose and excessive sweating decreased the likelihood. The proportion of patients with previous mild COVID-19 and impaired DLCO increased by 13% when the definition of impaired DLCO was < 80% predicted instead of below the LLN. When comparing previous studies, having severe COVID-19 increased the proportion of those with impaired DLCO by 21% compared to those with mild COVID-19. Conclusions One-third of patients with mild COVID-19 have impaired DLCO thirty-four days post-diagnosis. The criteria that define impaired DLCO and the severity of COVID-19 disease affects the proportion of those with impaired DLCO at follow-up. One-fifth of patients have a restrictive spirometric pattern. |
| first_indexed | 2024-04-12T08:22:38Z |
| format | Article |
| id | doaj.art-f820a7104c144461998239e649ddd7be |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-12T08:22:38Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-f820a7104c144461998239e649ddd7be2022-12-22T03:40:30ZengBMCBMC Pulmonary Medicine1471-24662022-07-012211810.1186/s12890-022-02086-9Clinical predictors of lung function in patients recovering from mild COVID-19Arturo Cortes-Telles0Esperanza Figueroa-Hurtado1Diana Lizbeth Ortiz-Farias2Gerald Stanley Zavorsky3Clínica de Enfermedades Respiratorias, Hospital Regional de Alta Especialidad de La Peninsula de YucatanClínica de Enfermedades Respiratorias, Hospital Regional de Alta Especialidad de La Peninsula de YucatanClínica de Enfermedades Respiratorias, Hospital Regional de Alta Especialidad de La Peninsula de YucatanDepartment of Physiology and Membrane Biology, University of CaliforniaAbstract Background Few studies have assessed lung function in Hispanic subjects recovering from mild COVID-19. Therefore, we examined the prevalence of impaired pulmonary diffusing capacity for carbon monoxide (DLCO) as defined by values below the lower limit of normal (< LLN, < 5th percentile) or less than 80% of predicted in Hispanics recovering from mild COVID-19. We also examined the prevalence of a restrictive spirometric pattern as defined by the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) being ≥ LLN with the FVC being < LLN. Finally, we evaluated previous studies to find factors correlated to impaired DLCO post-COVID-19. Methods In this observational study, adult patients (n = 146) with mild COVID-19 were recruited from a long-term follow-up COVID-19 clinic in Yucatan, Mexico, between March and August 2021. Spirometry, DLCO, and self-reported signs/symptoms were recorded 34 ± 4 days after diagnosis. Results At post-evaluation, 20% and 30% of patients recovering from COVID-19 were classified as having a restrictive spirometric pattern and impaired DLCO, respectively; 13% had both. The most prevalent reported symptoms were fatigue (73%), a persistent cough (43%), shortness of breath (42%) and a blocked/runny nose (36%). Increased age and a restrictive spirometric pattern increased the probability of having an impaired DLCO while having a blocked nose and excessive sweating decreased the likelihood. The proportion of patients with previous mild COVID-19 and impaired DLCO increased by 13% when the definition of impaired DLCO was < 80% predicted instead of below the LLN. When comparing previous studies, having severe COVID-19 increased the proportion of those with impaired DLCO by 21% compared to those with mild COVID-19. Conclusions One-third of patients with mild COVID-19 have impaired DLCO thirty-four days post-diagnosis. The criteria that define impaired DLCO and the severity of COVID-19 disease affects the proportion of those with impaired DLCO at follow-up. One-fifth of patients have a restrictive spirometric pattern.https://doi.org/10.1186/s12890-022-02086-9Respiratory function testSARS-CoV-2MexicoDLCOLung |
| spellingShingle | Arturo Cortes-Telles Esperanza Figueroa-Hurtado Diana Lizbeth Ortiz-Farias Gerald Stanley Zavorsky Clinical predictors of lung function in patients recovering from mild COVID-19 BMC Pulmonary Medicine Respiratory function test SARS-CoV-2 Mexico DLCO Lung |
| title | Clinical predictors of lung function in patients recovering from mild COVID-19 |
| title_full | Clinical predictors of lung function in patients recovering from mild COVID-19 |
| title_fullStr | Clinical predictors of lung function in patients recovering from mild COVID-19 |
| title_full_unstemmed | Clinical predictors of lung function in patients recovering from mild COVID-19 |
| title_short | Clinical predictors of lung function in patients recovering from mild COVID-19 |
| title_sort | clinical predictors of lung function in patients recovering from mild covid 19 |
| topic | Respiratory function test SARS-CoV-2 Mexico DLCO Lung |
| url | https://doi.org/10.1186/s12890-022-02086-9 |
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