p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease
p38γ MAPK (also called ERK6 or SAPK3) is a family member of stress-activated MAPKs and has common and specific roles as compared to other p38 proteins in signal transduction. Recent studies showed that, in addition to inflammation, p38γ metabolic signaling is involved in physiological exercise and i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/13/1674 |
| _version_ | 1827735103942426624 |
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| author | Xiao-Mei Qi Guan Chen |
| author_facet | Xiao-Mei Qi Guan Chen |
| author_sort | Xiao-Mei Qi |
| collection | DOAJ |
| description | p38γ MAPK (also called ERK6 or SAPK3) is a family member of stress-activated MAPKs and has common and specific roles as compared to other p38 proteins in signal transduction. Recent studies showed that, in addition to inflammation, p38γ metabolic signaling is involved in physiological exercise and in pathogenesis of cancer, diabetes, and Alzheimer’s disease, indicating its potential as a therapeutic target. p38γphosphorylates at least 19 substrates through which p38γ activity is further modified to regulate life-important cellular processes such as proliferation, differentiation, cell death, and transformation, thereby impacting biological outcomes of p38γ-driven pathogenesis. P38γ signaling is characterized by its unique reciprocal regulation with its specific phosphatase PTPH1 and by its direct binding to promoter DNAs, leading to transcriptional activation of targets including cancer-like stem cell drivers. This paper will review recent findings about p38γ inflammation and metabolic signaling in physiology and diseases. Moreover, we will discuss the progress in the development of p38γ-specific pharmacological inhibitors for therapeutic intervention in disease prevention and treatment by targeting the p38γ signaling network. |
| first_indexed | 2024-03-11T01:45:41Z |
| format | Article |
| id | doaj.art-f82237967aa148a784c6fb143fac468d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T01:45:41Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f82237967aa148a784c6fb143fac468d2023-11-18T16:18:24ZengMDPI AGCells2073-44092023-06-011213167410.3390/cells12131674p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and DiseaseXiao-Mei Qi0Guan Chen1Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USAp38γ MAPK (also called ERK6 or SAPK3) is a family member of stress-activated MAPKs and has common and specific roles as compared to other p38 proteins in signal transduction. Recent studies showed that, in addition to inflammation, p38γ metabolic signaling is involved in physiological exercise and in pathogenesis of cancer, diabetes, and Alzheimer’s disease, indicating its potential as a therapeutic target. p38γphosphorylates at least 19 substrates through which p38γ activity is further modified to regulate life-important cellular processes such as proliferation, differentiation, cell death, and transformation, thereby impacting biological outcomes of p38γ-driven pathogenesis. P38γ signaling is characterized by its unique reciprocal regulation with its specific phosphatase PTPH1 and by its direct binding to promoter DNAs, leading to transcriptional activation of targets including cancer-like stem cell drivers. This paper will review recent findings about p38γ inflammation and metabolic signaling in physiology and diseases. Moreover, we will discuss the progress in the development of p38γ-specific pharmacological inhibitors for therapeutic intervention in disease prevention and treatment by targeting the p38γ signaling network.https://www.mdpi.com/2073-4409/12/13/1674p38γsignal transductioncancer |
| spellingShingle | Xiao-Mei Qi Guan Chen p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease Cells p38γ signal transduction cancer |
| title | p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease |
| title_full | p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease |
| title_fullStr | p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease |
| title_full_unstemmed | p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease |
| title_short | p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease |
| title_sort | p38γ mapk inflammatory and metabolic signaling in physiology and disease |
| topic | p38γ signal transduction cancer |
| url | https://www.mdpi.com/2073-4409/12/13/1674 |
| work_keys_str_mv | AT xiaomeiqi p38gmapkinflammatoryandmetabolicsignalinginphysiologyanddisease AT guanchen p38gmapkinflammatoryandmetabolicsignalinginphysiologyanddisease |