BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats
In recent years, obesity has become an important risk factor for human health; how to effectively prevent and reduce the occurrence of obesity is a hot research topic in recent years. Hypoxic training effectively improves abnormalities of lipid metabolism caused by obesity. The current study explore...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.882151/full |
| _version_ | 1818244543560024064 |
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| author | Junpeng Feng Junpeng Feng Xuebing Wang Xuebing Wang Yingli Lu Chang Yu Xinyan Wang Lianshi Feng |
| author_facet | Junpeng Feng Junpeng Feng Xuebing Wang Xuebing Wang Yingli Lu Chang Yu Xinyan Wang Lianshi Feng |
| author_sort | Junpeng Feng |
| collection | DOAJ |
| description | In recent years, obesity has become an important risk factor for human health; how to effectively prevent and reduce the occurrence of obesity is a hot research topic in recent years. Hypoxic training effectively improves abnormalities of lipid metabolism caused by obesity. The current study explored the effects of hypoxic training on BAIBA secretion and white fat browning in inguinal fat in obese rats. Analyses were performed by HPLC/MS/MS—MS/MS, RT-q PCR and western blot methods. The findings showed that 4 weeks of hypoxic training reduced body weight, Lee’s index, and regulated blood lipid profile in obese rats. Hypoxic training up-regulated BAIBA concentration in gastrocnemius muscle and circulation in obese rats. Hypoxic training significantly upregulated expression of PPARα and UCP-1 in inguinal fat of obese rats and increased white fat browning. The findings showed that BAIBA may involve in improveing blood lipid profile and white fat browning by modulating PPARα and UCP-1 expression. |
| first_indexed | 2024-12-12T14:18:42Z |
| format | Article |
| id | doaj.art-f823349a61414292bd9e04d4659a6308 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T14:18:42Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-f823349a61414292bd9e04d4659a63082022-12-22T00:21:51ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-06-011310.3389/fphys.2022.882151882151BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese RatsJunpeng Feng0Junpeng Feng1Xuebing Wang2Xuebing Wang3Yingli Lu4Chang Yu5Xinyan Wang6Lianshi Feng7Exercise Biology Research Center, China Institute of Sport Science, Beijing, ChinaSchool of Sport Science, Beijing Sport University, Beijing, ChinaExercise Biology Research Center, China Institute of Sport Science, Beijing, ChinaCollege of Physical Education, Guangxi University, Nanning, ChinaExercise Biology Research Center, China Institute of Sport Science, Beijing, ChinaExercise Biology Research Center, China Institute of Sport Science, Beijing, ChinaExercise Biology Research Center, China Institute of Sport Science, Beijing, ChinaExercise Biology Research Center, China Institute of Sport Science, Beijing, ChinaIn recent years, obesity has become an important risk factor for human health; how to effectively prevent and reduce the occurrence of obesity is a hot research topic in recent years. Hypoxic training effectively improves abnormalities of lipid metabolism caused by obesity. The current study explored the effects of hypoxic training on BAIBA secretion and white fat browning in inguinal fat in obese rats. Analyses were performed by HPLC/MS/MS—MS/MS, RT-q PCR and western blot methods. The findings showed that 4 weeks of hypoxic training reduced body weight, Lee’s index, and regulated blood lipid profile in obese rats. Hypoxic training up-regulated BAIBA concentration in gastrocnemius muscle and circulation in obese rats. Hypoxic training significantly upregulated expression of PPARα and UCP-1 in inguinal fat of obese rats and increased white fat browning. The findings showed that BAIBA may involve in improveing blood lipid profile and white fat browning by modulating PPARα and UCP-1 expression.https://www.frontiersin.org/articles/10.3389/fphys.2022.882151/fullhypoxic trainingobesityBAIBAlipid metabolismbrowning |
| spellingShingle | Junpeng Feng Junpeng Feng Xuebing Wang Xuebing Wang Yingli Lu Chang Yu Xinyan Wang Lianshi Feng BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats Frontiers in Physiology hypoxic training obesity BAIBA lipid metabolism browning |
| title | BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats |
| title_full | BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats |
| title_fullStr | BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats |
| title_full_unstemmed | BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats |
| title_short | BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats |
| title_sort | baiba involves in hypoxic training induced browning of white adipose tissue in obese rats |
| topic | hypoxic training obesity BAIBA lipid metabolism browning |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.882151/full |
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