Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies
<p>The increased oral <em>Candida </em>colonization that resulted for radiotherapy often leads to candidiasis. Intensity Modulated Radiotherapy (IMRT) is a technique of delivering radiation with improved dose distributions sparing the surrounding normal tissue and decreasing the il...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Dentistry, Universitas Indonesia
2017-04-01
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| Series: | Journal of Dentistry Indonesia |
| Subjects: | |
| Online Access: | http://jdentistry.ui.ac.id/index.php/JDI/article/view/1078 |
| Summary: | <p>The increased oral <em>Candida </em>colonization that resulted for radiotherapy often leads to candidiasis. Intensity Modulated Radiotherapy (IMRT) is a technique of delivering radiation with improved dose distributions sparing the surrounding normal tissue and decreasing the ill-effects. <strong>Objective: </strong>To identify and quantify changes in the <em>Candidal </em>carriage of patients undergoing IMRT for head and neck malignancy. <strong>Methods: </strong>Saliva from 37 patients undergoing IMRT for head and neck malignancy was collected. The <em>Candida </em>species profile pre- and post-IMRT was evaluated using semi quantitative fungal culture. The changes in the distribution of the growth of Candida species due to IMRT was analyzed using Wilcoxon sign rank test. <strong>Results: </strong>Twenty-two patients were <em>Candida</em>-positive pre-IMRT, while 24 patients were <em>Candida</em>-positive post-IMRT. <em>Candida </em>species isolates pre-IMRT were <em>C</em>. <em>albicans </em>(63%)<em>, C. tropicalis </em>(26%), <em>C. glabrata </em>(7%)<em>, C. krusei </em>(4%) and post-IMRT, were <em>C. albicans </em>(55%)<em>, C. tropicalis </em>(30%), <em>C. glabrata </em>(12%) and <em>C. krusei </em>(3%). <em>C. albicans </em>showed increased growth post-IMRT in the range of 103 to 104 colony-forming units per ml of saliva (p>0.05). <strong>Conclusion: </strong>There was no significant effect of IMRT on the distribution of growth of Candida. <em>Candida albicans </em>was the most common species. A change towards non <em>C. albicans </em>species post-IMRT was seen.</p><p> </p> |
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| ISSN: | 1693-9697 2355-4800 |