Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies
<p>The increased oral <em>Candida </em>colonization that resulted for radiotherapy often leads to candidiasis. Intensity Modulated Radiotherapy (IMRT) is a technique of delivering radiation with improved dose distributions sparing the surrounding normal tissue and decreasing the il...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Dentistry, Universitas Indonesia
2017-04-01
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| Series: | Journal of Dentistry Indonesia |
| Subjects: | |
| Online Access: | http://jdentistry.ui.ac.id/index.php/JDI/article/view/1078 |
| _version_ | 1828368646986006528 |
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| author | Jasmine Shanthi Kamath Raghavendra Kini Vathsala Naik Anup Kumar Shetty |
| author_facet | Jasmine Shanthi Kamath Raghavendra Kini Vathsala Naik Anup Kumar Shetty |
| author_sort | Jasmine Shanthi Kamath |
| collection | DOAJ |
| description | <p>The increased oral <em>Candida </em>colonization that resulted for radiotherapy often leads to candidiasis. Intensity Modulated Radiotherapy (IMRT) is a technique of delivering radiation with improved dose distributions sparing the surrounding normal tissue and decreasing the ill-effects. <strong>Objective: </strong>To identify and quantify changes in the <em>Candidal </em>carriage of patients undergoing IMRT for head and neck malignancy. <strong>Methods: </strong>Saliva from 37 patients undergoing IMRT for head and neck malignancy was collected. The <em>Candida </em>species profile pre- and post-IMRT was evaluated using semi quantitative fungal culture. The changes in the distribution of the growth of Candida species due to IMRT was analyzed using Wilcoxon sign rank test. <strong>Results: </strong>Twenty-two patients were <em>Candida</em>-positive pre-IMRT, while 24 patients were <em>Candida</em>-positive post-IMRT. <em>Candida </em>species isolates pre-IMRT were <em>C</em>. <em>albicans </em>(63%)<em>, C. tropicalis </em>(26%), <em>C. glabrata </em>(7%)<em>, C. krusei </em>(4%) and post-IMRT, were <em>C. albicans </em>(55%)<em>, C. tropicalis </em>(30%), <em>C. glabrata </em>(12%) and <em>C. krusei </em>(3%). <em>C. albicans </em>showed increased growth post-IMRT in the range of 103 to 104 colony-forming units per ml of saliva (p>0.05). <strong>Conclusion: </strong>There was no significant effect of IMRT on the distribution of growth of Candida. <em>Candida albicans </em>was the most common species. A change towards non <em>C. albicans </em>species post-IMRT was seen.</p><p> </p> |
| first_indexed | 2024-04-14T06:13:39Z |
| format | Article |
| id | doaj.art-f823ac27b613478ea76f5e15ac8933f3 |
| institution | Directory Open Access Journal |
| issn | 1693-9697 2355-4800 |
| language | English |
| last_indexed | 2024-04-14T06:13:39Z |
| publishDate | 2017-04-01 |
| publisher | Faculty of Dentistry, Universitas Indonesia |
| record_format | Article |
| series | Journal of Dentistry Indonesia |
| spelling | doaj.art-f823ac27b613478ea76f5e15ac8933f32022-12-22T02:08:18ZengFaculty of Dentistry, Universitas IndonesiaJournal of Dentistry Indonesia1693-96972355-48002017-04-0124171210.14693/jdi.v24i1.1078873Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck MalignanciesJasmine Shanthi Kamath0Raghavendra Kini1Vathsala Naik2Anup Kumar Shetty3Department of Oral Medicine and Radiology, A. Shetty Memorial Institute Dental Sciences, Nitte University, Mangalore 575018Department of Oral Medicine and Radiology A. J. Institute of Dental Sciences, Mangalore 575004, KarnatakaDepartment of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences, Bangalore 560027, KarnatakaDepartment of Microbiology, Father Muller Medical College Hospital, Mangalore - 575 002, Karnataka<p>The increased oral <em>Candida </em>colonization that resulted for radiotherapy often leads to candidiasis. Intensity Modulated Radiotherapy (IMRT) is a technique of delivering radiation with improved dose distributions sparing the surrounding normal tissue and decreasing the ill-effects. <strong>Objective: </strong>To identify and quantify changes in the <em>Candidal </em>carriage of patients undergoing IMRT for head and neck malignancy. <strong>Methods: </strong>Saliva from 37 patients undergoing IMRT for head and neck malignancy was collected. The <em>Candida </em>species profile pre- and post-IMRT was evaluated using semi quantitative fungal culture. The changes in the distribution of the growth of Candida species due to IMRT was analyzed using Wilcoxon sign rank test. <strong>Results: </strong>Twenty-two patients were <em>Candida</em>-positive pre-IMRT, while 24 patients were <em>Candida</em>-positive post-IMRT. <em>Candida </em>species isolates pre-IMRT were <em>C</em>. <em>albicans </em>(63%)<em>, C. tropicalis </em>(26%), <em>C. glabrata </em>(7%)<em>, C. krusei </em>(4%) and post-IMRT, were <em>C. albicans </em>(55%)<em>, C. tropicalis </em>(30%), <em>C. glabrata </em>(12%) and <em>C. krusei </em>(3%). <em>C. albicans </em>showed increased growth post-IMRT in the range of 103 to 104 colony-forming units per ml of saliva (p>0.05). <strong>Conclusion: </strong>There was no significant effect of IMRT on the distribution of growth of Candida. <em>Candida albicans </em>was the most common species. A change towards non <em>C. albicans </em>species post-IMRT was seen.</p><p> </p>http://jdentistry.ui.ac.id/index.php/JDI/article/view/1078Candidahead and neck malignancyIMRTradiotherapy |
| spellingShingle | Jasmine Shanthi Kamath Raghavendra Kini Vathsala Naik Anup Kumar Shetty Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies Journal of Dentistry Indonesia Candida head and neck malignancy IMRT radiotherapy |
| title | Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies |
| title_full | Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies |
| title_fullStr | Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies |
| title_full_unstemmed | Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies |
| title_short | Changes in Candida Profile in Patients Undergoing Intensity Modulated Radiotherapy for Head and Neck Malignancies |
| title_sort | changes in candida profile in patients undergoing intensity modulated radiotherapy for head and neck malignancies |
| topic | Candida head and neck malignancy IMRT radiotherapy |
| url | http://jdentistry.ui.ac.id/index.php/JDI/article/view/1078 |
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