Challenges and prospects in geriatric epilepsy treatment: the role of the blood–brain barrier in pharmacotherapy and drug delivery
The blood–brain barrier (BBB) is pivotal in maintaining neuronal physiology within the brain. This review delves into the alterations of the BBB specifically in the context of geriatric epilepsy. We examine how age-related changes in the BBB contribute to the pathogenesis of epilepsy in the elderly...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1342366/full |
| _version_ | 1827355914787618816 |
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| author | Xin Chen Juan Luo Juan Luo Min Song Liang Pan Zhichuang Qu Bo Huang Sixun Yu Haifeng Shu Haifeng Shu |
| author_facet | Xin Chen Juan Luo Juan Luo Min Song Liang Pan Zhichuang Qu Bo Huang Sixun Yu Haifeng Shu Haifeng Shu |
| author_sort | Xin Chen |
| collection | DOAJ |
| description | The blood–brain barrier (BBB) is pivotal in maintaining neuronal physiology within the brain. This review delves into the alterations of the BBB specifically in the context of geriatric epilepsy. We examine how age-related changes in the BBB contribute to the pathogenesis of epilepsy in the elderly and present significant challenges in pharmacotherapy. Subsequently, we evaluate recent advancements in drug delivery methods targeting the BBB, as well as alternative approaches that could bypass the BBB’s restrictive nature. We particularly highlight the use of neurotropic viruses and various synthetic nanoparticles that have been investigated for delivering a range of antiepileptic drugs. Additionally, the advantage and limitation of these diverse delivery methods are discussed. Finally, we analyze the potential efficacy of different drug delivery approaches in the treatment of geriatric epilepsy, aiming to provide insights into more effective management of this condition in the elderly population. |
| first_indexed | 2024-03-08T04:50:14Z |
| format | Article |
| id | doaj.art-f8254463596e489dbffb547d61d60fd1 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-08T04:50:14Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-f8254463596e489dbffb547d61d60fd12024-02-08T05:18:51ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-02-011610.3389/fnagi.2024.13423661342366Challenges and prospects in geriatric epilepsy treatment: the role of the blood–brain barrier in pharmacotherapy and drug deliveryXin Chen0Juan Luo1Juan Luo2Min Song3Liang Pan4Zhichuang Qu5Bo Huang6Sixun Yu7Haifeng Shu8Haifeng Shu9Department of Neurosurgery, Western Theater General Hospital, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, Western Theater General Hospital, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Neurosurgery, Western Theater General Hospital, Chengdu, Sichuan, ChinaDepartment of Pediatrics, Western Theater General Hospital, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, Meishan City People's Hospital, Meishan, Sichuan, ChinaDepartment of Burn and Plastic, Western Theater General Hospital, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, Western Theater General Hospital, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, Western Theater General Hospital, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaThe blood–brain barrier (BBB) is pivotal in maintaining neuronal physiology within the brain. This review delves into the alterations of the BBB specifically in the context of geriatric epilepsy. We examine how age-related changes in the BBB contribute to the pathogenesis of epilepsy in the elderly and present significant challenges in pharmacotherapy. Subsequently, we evaluate recent advancements in drug delivery methods targeting the BBB, as well as alternative approaches that could bypass the BBB’s restrictive nature. We particularly highlight the use of neurotropic viruses and various synthetic nanoparticles that have been investigated for delivering a range of antiepileptic drugs. Additionally, the advantage and limitation of these diverse delivery methods are discussed. Finally, we analyze the potential efficacy of different drug delivery approaches in the treatment of geriatric epilepsy, aiming to provide insights into more effective management of this condition in the elderly population.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1342366/fullblood–brain barriergeriatric epilepsyantiepileptic therapyantiepileptic drugnanoparticle |
| spellingShingle | Xin Chen Juan Luo Juan Luo Min Song Liang Pan Zhichuang Qu Bo Huang Sixun Yu Haifeng Shu Haifeng Shu Challenges and prospects in geriatric epilepsy treatment: the role of the blood–brain barrier in pharmacotherapy and drug delivery Frontiers in Aging Neuroscience blood–brain barrier geriatric epilepsy antiepileptic therapy antiepileptic drug nanoparticle |
| title | Challenges and prospects in geriatric epilepsy treatment: the role of the blood–brain barrier in pharmacotherapy and drug delivery |
| title_full | Challenges and prospects in geriatric epilepsy treatment: the role of the blood–brain barrier in pharmacotherapy and drug delivery |
| title_fullStr | Challenges and prospects in geriatric epilepsy treatment: the role of the blood–brain barrier in pharmacotherapy and drug delivery |
| title_full_unstemmed | Challenges and prospects in geriatric epilepsy treatment: the role of the blood–brain barrier in pharmacotherapy and drug delivery |
| title_short | Challenges and prospects in geriatric epilepsy treatment: the role of the blood–brain barrier in pharmacotherapy and drug delivery |
| title_sort | challenges and prospects in geriatric epilepsy treatment the role of the blood brain barrier in pharmacotherapy and drug delivery |
| topic | blood–brain barrier geriatric epilepsy antiepileptic therapy antiepileptic drug nanoparticle |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1342366/full |
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