Box–Behnken Design Used to Optimize the Simultaneous Quantification of Amitriptyline and Propranolol in Tablet Dosages by RP-HPLC-DAD Method and Their Stability Tests

Box–Behnken Design Used to Optimize the Simultaneous Quantification of Amitriptyline and Propranolol in Tablet Dosages by RP-HPLC-DAD Method and Their Stability Tests

This study’s goal is to use a Box–Behnken design [BBD] methodology to create a new reverse-phase high-performance liquid chromatography diode-array detection [RP-HPLC-DAD] method for the simultaneous quantification of Amitriptyline and Propranolol in tablet dosages. The amitriptyline and propranolol...

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Bibliographic Details
Main Authors: Mohammad Khalid, Sarfaraz Ahmad
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Separations
Subjects:
RP-HPLC–DAD
BBD
ICH guidelines
stability studies
assay
Online Access:https://www.mdpi.com/2297-8739/9/12/421

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