Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain
The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokine signalling by non-canonical autophagy.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19670-4 |
| _version_ | 1818841364448673792 |
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| author | Inmaculada Serramito-Gómez Emilio Boada-Romero Raquel Villamuera Álvaro Fernández-Cabrera José Luis Cedillo Ángela Martín-Regalado Simon Carding Uli Mayer Penny P. Powell Thomas Wileman Irene García-Higuera Felipe X. Pimentel-Muiños |
| author_facet | Inmaculada Serramito-Gómez Emilio Boada-Romero Raquel Villamuera Álvaro Fernández-Cabrera José Luis Cedillo Ángela Martín-Regalado Simon Carding Uli Mayer Penny P. Powell Thomas Wileman Irene García-Higuera Felipe X. Pimentel-Muiños |
| author_sort | Inmaculada Serramito-Gómez |
| collection | DOAJ |
| description | The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokine signalling by non-canonical autophagy. |
| first_indexed | 2024-12-19T04:24:54Z |
| format | Article |
| id | doaj.art-f827951d5bc9452e960cbed014b2d5d6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:24:54Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f827951d5bc9452e960cbed014b2d5d62022-12-21T20:36:04ZengNature PortfolioNature Communications2041-17232020-11-0111111510.1038/s41467-020-19670-4Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domainInmaculada Serramito-Gómez0Emilio Boada-Romero1Raquel Villamuera2Álvaro Fernández-Cabrera3José Luis Cedillo4Ángela Martín-Regalado5Simon Carding6Uli Mayer7Penny P. Powell8Thomas Wileman9Irene García-Higuera10Felipe X. Pimentel-Muiños11Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de SalamancaInstituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de SalamancaInstituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de SalamancaInstituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de SalamancaInstituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de SalamancaInstituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de SalamancaQuadram Institute Bioscience, Norwich Research ParkSchool of Biological Sciences, University of East AngliaNorwich Medical School, University of East AngliaQuadram Institute Bioscience, Norwich Research ParkDepartamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Universidad Autónoma de MadridInstituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de SalamancaThe WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokine signalling by non-canonical autophagy.https://doi.org/10.1038/s41467-020-19670-4 |
| spellingShingle | Inmaculada Serramito-Gómez Emilio Boada-Romero Raquel Villamuera Álvaro Fernández-Cabrera José Luis Cedillo Ángela Martín-Regalado Simon Carding Uli Mayer Penny P. Powell Thomas Wileman Irene García-Higuera Felipe X. Pimentel-Muiños Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain Nature Communications |
| title | Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain |
| title_full | Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain |
| title_fullStr | Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain |
| title_full_unstemmed | Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain |
| title_short | Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain |
| title_sort | regulation of cytokine signaling through direct interaction between cytokine receptors and the atg16l1 wd40 domain |
| url | https://doi.org/10.1038/s41467-020-19670-4 |
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