Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokine signalling by non-canonical autophagy.

Bibliographic Details
Main Authors: Inmaculada Serramito-Gómez, Emilio Boada-Romero, Raquel Villamuera, Álvaro Fernández-Cabrera, José Luis Cedillo, Ángela Martín-Regalado, Simon Carding, Uli Mayer, Penny P. Powell, Thomas Wileman, Irene García-Higuera, Felipe X. Pimentel-Muiños
Format: Article
Language:English
Published: Nature Portfolio 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19670-4

Internet

https://doi.org/10.1038/s41467-020-19670-4

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