COVID-19 vaccines portray the bright side of human creativity, but it means nothing until they prove their worth: A Study on Seroconversion after the first Dose of Covishield vaccine in central Kerala
Background: COVID-19 vaccines, we believe, have come to rescue us from the clutches of the dreaded severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With rapid ongoing mutations, it is difficult to predict the effectiveness of seroconversion following vaccination. This study aims to find...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Community Medicine |
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| Online Access: | http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2022;volume=47;issue=2;spage=213;epage=217;aulast=Varghese |
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| author | Sangeetha Merrin Varghese Arun Sachu Linda Jacob Geomcy George George Mateethra Chandy Abel K Samuel Johnson Grace Mary John |
| author_facet | Sangeetha Merrin Varghese Arun Sachu Linda Jacob Geomcy George George Mateethra Chandy Abel K Samuel Johnson Grace Mary John |
| author_sort | Sangeetha Merrin Varghese |
| collection | DOAJ |
| description | Background: COVID-19 vaccines, we believe, have come to rescue us from the clutches of the dreaded severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With rapid ongoing mutations, it is difficult to predict the effectiveness of seroconversion following vaccination. This study aims to find out the proportion of people with seroconversion following first dose of Covishield vaccine. Methods: Randomly selected health-care workers were followed up for SARS-CoV-2 immunoglobulin G (IgG) antibodies between 28 and 42 days after receiving their first vaccine dose. The VITROS SARS-CoV-2 IgG test (Ortho-Clinical Diagnostics, USA) with 100% specificity and > 90% sensitivity was used to assess seroconversion. Results: The first dose of vaccine induced seroconversion in 91.7% of beneficiaries. Nearly one-third (30.2%) of them had high antibody titers, and it showed a significant association with female gender (9.6 ± 5.5 vs. 7.6 ± 5.6) and younger age (P = 0.008). In addition, those with previous COVID infection showed a more robust immune response when compared to others (P = 0.001). Conclusion: Seroconversion rate of more than 90% offers a promising hope toward successful pandemic control. In the current scenario, the inability to attain the targeted coverage due to an upsurge in vaccine hesitancy, compounded with only lower proportion of seroconversion in elderly, faster rollout of the vaccines without any age limit, will help achieve the herd threshold more rapidly. |
| first_indexed | 2024-12-12T01:31:07Z |
| format | Article |
| id | doaj.art-f827a31667684da6961dd1ad0be1f46b |
| institution | Directory Open Access Journal |
| issn | 0970-0218 1998-3581 |
| language | English |
| last_indexed | 2024-12-12T01:31:07Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Community Medicine |
| spelling | doaj.art-f827a31667684da6961dd1ad0be1f46b2022-12-22T00:42:59ZengWolters Kluwer Medknow PublicationsIndian Journal of Community Medicine0970-02181998-35812022-01-0147221321710.4103/ijcm.ijcm_671_21COVID-19 vaccines portray the bright side of human creativity, but it means nothing until they prove their worth: A Study on Seroconversion after the first Dose of Covishield vaccine in central KeralaSangeetha Merrin VargheseArun SachuLinda JacobGeomcy GeorgeGeorge Mateethra ChandyAbel K Samuel JohnsonGrace Mary JohnBackground: COVID-19 vaccines, we believe, have come to rescue us from the clutches of the dreaded severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With rapid ongoing mutations, it is difficult to predict the effectiveness of seroconversion following vaccination. This study aims to find out the proportion of people with seroconversion following first dose of Covishield vaccine. Methods: Randomly selected health-care workers were followed up for SARS-CoV-2 immunoglobulin G (IgG) antibodies between 28 and 42 days after receiving their first vaccine dose. The VITROS SARS-CoV-2 IgG test (Ortho-Clinical Diagnostics, USA) with 100% specificity and > 90% sensitivity was used to assess seroconversion. Results: The first dose of vaccine induced seroconversion in 91.7% of beneficiaries. Nearly one-third (30.2%) of them had high antibody titers, and it showed a significant association with female gender (9.6 ± 5.5 vs. 7.6 ± 5.6) and younger age (P = 0.008). In addition, those with previous COVID infection showed a more robust immune response when compared to others (P = 0.001). Conclusion: Seroconversion rate of more than 90% offers a promising hope toward successful pandemic control. In the current scenario, the inability to attain the targeted coverage due to an upsurge in vaccine hesitancy, compounded with only lower proportion of seroconversion in elderly, faster rollout of the vaccines without any age limit, will help achieve the herd threshold more rapidly.http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2022;volume=47;issue=2;spage=213;epage=217;aulast=Varghesecovishield vaccinefirst doseoxford–astrazeneca vaccineseroconversion |
| spellingShingle | Sangeetha Merrin Varghese Arun Sachu Linda Jacob Geomcy George George Mateethra Chandy Abel K Samuel Johnson Grace Mary John COVID-19 vaccines portray the bright side of human creativity, but it means nothing until they prove their worth: A Study on Seroconversion after the first Dose of Covishield vaccine in central Kerala Indian Journal of Community Medicine covishield vaccine first dose oxford–astrazeneca vaccine seroconversion |
| title | COVID-19 vaccines portray the bright side of human creativity, but it means nothing until they prove their worth: A Study on Seroconversion after the first Dose of Covishield vaccine in central Kerala |
| title_full | COVID-19 vaccines portray the bright side of human creativity, but it means nothing until they prove their worth: A Study on Seroconversion after the first Dose of Covishield vaccine in central Kerala |
| title_fullStr | COVID-19 vaccines portray the bright side of human creativity, but it means nothing until they prove their worth: A Study on Seroconversion after the first Dose of Covishield vaccine in central Kerala |
| title_full_unstemmed | COVID-19 vaccines portray the bright side of human creativity, but it means nothing until they prove their worth: A Study on Seroconversion after the first Dose of Covishield vaccine in central Kerala |
| title_short | COVID-19 vaccines portray the bright side of human creativity, but it means nothing until they prove their worth: A Study on Seroconversion after the first Dose of Covishield vaccine in central Kerala |
| title_sort | covid 19 vaccines portray the bright side of human creativity but it means nothing until they prove their worth a study on seroconversion after the first dose of covishield vaccine in central kerala |
| topic | covishield vaccine first dose oxford–astrazeneca vaccine seroconversion |
| url | http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2022;volume=47;issue=2;spage=213;epage=217;aulast=Varghese |
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