Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor
Interdigitating dendritic cell sarcoma is extremely rare neoplasm that mainly occurs in the lymph nodes. Only 45 cases have been reported in the literature to date. We report a case of this sarcoma arising from the liver and lung, a previosly unreported site for this neoplasm. An 19-year-old girl...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2012-08-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2485 |
| _version_ | 1797260924513419264 |
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| author | Svjetlana Radović Mirsad Dorić Hamza Žujo Ajna Hukić Suada Kuskunović Mirsad Babić Ivana Tomić |
| author_facet | Svjetlana Radović Mirsad Dorić Hamza Žujo Ajna Hukić Suada Kuskunović Mirsad Babić Ivana Tomić |
| author_sort | Svjetlana Radović |
| collection | DOAJ |
| description | Interdigitating dendritic cell sarcoma is extremely rare neoplasm that mainly occurs in the lymph nodes. Only 45 cases have been reported in the literature to date.
We report a case of this sarcoma arising from the liver and lung, a previosly unreported site for this neoplasm. An 19-year-old girl deteriorated rapidly after artificial abortion and died 4 weeks later. Autopsy showed markedly enlarged liver and lung with numerous nodules up to 0.5 centimeters in diameter. Microscopically, nodules was composed of large pleomorphic cells that were immunohistochemically positive for proteins S-100 and vimentin, some of them expressed positivity to fascin and CD 68, with a rich small CD3 positive T lymphocytic infiltrateite around them.
Based of these findings, the present case was diagnosed as interdigitating dendritic cell sarcoma, a neoplasm that remains a diagnostic and clinical challenge, because it can mimic a wide variety of other malignant tumors and tumor-like lesions.
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| first_indexed | 2024-04-24T23:33:03Z |
| format | Article |
| id | doaj.art-f82930b5ea084a89a1e87ea0adb40259 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:33:03Z |
| publishDate | 2012-08-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-f82930b5ea084a89a1e87ea0adb402592024-03-15T14:33:50ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2012-08-0112310.17305/bjbms.2012.2485286Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumorSvjetlana Radović0Mirsad Dorić1Hamza Žujo2Ajna Hukić3Suada Kuskunović4Mirsad Babić5Ivana Tomić6Institute of Pathology, Medical Faculty, University of SarajevoInstitute of Pathology, Medical Faculty, University of SarajevoInstitute of Forensic Medicine, Medical Faculty, University of SarajevoInstitute of Pathology, Medical Faculty, University of SarajevoInstitute of Pathology, Medical Faculty, University of SarajevoInstitute of Pathology, Medical Faculty, University of SarajevoInstitute of Pathology, Medical Faculty, University of SarajevoInterdigitating dendritic cell sarcoma is extremely rare neoplasm that mainly occurs in the lymph nodes. Only 45 cases have been reported in the literature to date. We report a case of this sarcoma arising from the liver and lung, a previosly unreported site for this neoplasm. An 19-year-old girl deteriorated rapidly after artificial abortion and died 4 weeks later. Autopsy showed markedly enlarged liver and lung with numerous nodules up to 0.5 centimeters in diameter. Microscopically, nodules was composed of large pleomorphic cells that were immunohistochemically positive for proteins S-100 and vimentin, some of them expressed positivity to fascin and CD 68, with a rich small CD3 positive T lymphocytic infiltrateite around them. Based of these findings, the present case was diagnosed as interdigitating dendritic cell sarcoma, a neoplasm that remains a diagnostic and clinical challenge, because it can mimic a wide variety of other malignant tumors and tumor-like lesions. https://www.bjbms.org/ojs/index.php/bjbms/article/view/2485interdigital dendritic cellssarcomaextranodal location |
| spellingShingle | Svjetlana Radović Mirsad Dorić Hamza Žujo Ajna Hukić Suada Kuskunović Mirsad Babić Ivana Tomić Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor Biomolecules & Biomedicine interdigital dendritic cells sarcoma extranodal location |
| title | Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor |
| title_full | Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor |
| title_fullStr | Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor |
| title_full_unstemmed | Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor |
| title_short | Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor |
| title_sort | interdigitating dendritic cell sarcoma of the liver and lung a case report with morphohological and immunohistochemical features of tumor |
| topic | interdigital dendritic cells sarcoma extranodal location |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2485 |
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