Increased monocytic myeloid-derived suppressor cells in type 2 diabetes correlate with hyperglycemic and was a risk factor of infection and tumor occurrence
Abstract To investigate the frequency of monocytic myeloid-derived suppressor cells (M-MDSCs) in type 2 diabetes mellitus (T2DM) patients and explore the potential associations between M-MDSCs, glycemic control, and the occurrence of infections and tumor. 102 healthy and 77 T2DM individuals were enr...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-54496-w |
| _version_ | 1797274760194818048 |
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| author | Ji Zhou Mengjie Zhang Xiaodi Ju Huiping Wang Hao Xiao Zhimin Zhai Xing Zhong Jingfang Hong |
| author_facet | Ji Zhou Mengjie Zhang Xiaodi Ju Huiping Wang Hao Xiao Zhimin Zhai Xing Zhong Jingfang Hong |
| author_sort | Ji Zhou |
| collection | DOAJ |
| description | Abstract To investigate the frequency of monocytic myeloid-derived suppressor cells (M-MDSCs) in type 2 diabetes mellitus (T2DM) patients and explore the potential associations between M-MDSCs, glycemic control, and the occurrence of infections and tumor. 102 healthy and 77 T2DM individuals were enrolled. We assessed the M-MDSCs frequency, levels of fasting plasma glucose (FPG), haemoglobin A1c (HbA1c), and other relevant indicators. Each patient underwent a follow-up of at least 6 months after M-MDSCs detection. The M-MDSCs frequency was significantly higher in patients with poor glycemic control (PGC) compared to the healthy population (P < 0.001), whereas there was no significant difference between patients with good glycemic control and the healthy (P > 0.05). There was a positive correlation between the M-MDSCs frequency and FPG, HbA1c (R = 0.517 and 0.315, P < 0.001, respectively). T2DM patients with abnormally increased M-MDSCs have a higher incidence of infection and tumor (48.57% and 11.43% respectively). Our results shed new light on the pathogenesis of T2DM, help to understand why T2DM patients are susceptible to infection and tumor and providing novel insights for future prevention and treatment of T2DM. |
| first_indexed | 2024-03-07T15:02:54Z |
| format | Article |
| id | doaj.art-f82b15c932f440c19338a4a39946aa2f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:02:54Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f82b15c932f440c19338a4a39946aa2f2024-03-05T19:03:36ZengNature PortfolioScientific Reports2045-23222024-02-0114111010.1038/s41598-024-54496-wIncreased monocytic myeloid-derived suppressor cells in type 2 diabetes correlate with hyperglycemic and was a risk factor of infection and tumor occurrenceJi Zhou0Mengjie Zhang1Xiaodi Ju2Huiping Wang3Hao Xiao4Zhimin Zhai5Xing Zhong6Jingfang Hong7Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Anhui Medical UniversitySchool of Nursing, Anhui Medical UniversityHematologic Department/Hematologic Disease Research Center, the Second Affiliated Hospital of Anhui Medical UniversityHematologic Department/Hematologic Disease Research Center, the Second Affiliated Hospital of Anhui Medical UniversityHematologic Department/Hematologic Disease Research Center, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Anhui Medical UniversitySchool of Nursing, Anhui Medical UniversityAbstract To investigate the frequency of monocytic myeloid-derived suppressor cells (M-MDSCs) in type 2 diabetes mellitus (T2DM) patients and explore the potential associations between M-MDSCs, glycemic control, and the occurrence of infections and tumor. 102 healthy and 77 T2DM individuals were enrolled. We assessed the M-MDSCs frequency, levels of fasting plasma glucose (FPG), haemoglobin A1c (HbA1c), and other relevant indicators. Each patient underwent a follow-up of at least 6 months after M-MDSCs detection. The M-MDSCs frequency was significantly higher in patients with poor glycemic control (PGC) compared to the healthy population (P < 0.001), whereas there was no significant difference between patients with good glycemic control and the healthy (P > 0.05). There was a positive correlation between the M-MDSCs frequency and FPG, HbA1c (R = 0.517 and 0.315, P < 0.001, respectively). T2DM patients with abnormally increased M-MDSCs have a higher incidence of infection and tumor (48.57% and 11.43% respectively). Our results shed new light on the pathogenesis of T2DM, help to understand why T2DM patients are susceptible to infection and tumor and providing novel insights for future prevention and treatment of T2DM.https://doi.org/10.1038/s41598-024-54496-w |
| spellingShingle | Ji Zhou Mengjie Zhang Xiaodi Ju Huiping Wang Hao Xiao Zhimin Zhai Xing Zhong Jingfang Hong Increased monocytic myeloid-derived suppressor cells in type 2 diabetes correlate with hyperglycemic and was a risk factor of infection and tumor occurrence Scientific Reports |
| title | Increased monocytic myeloid-derived suppressor cells in type 2 diabetes correlate with hyperglycemic and was a risk factor of infection and tumor occurrence |
| title_full | Increased monocytic myeloid-derived suppressor cells in type 2 diabetes correlate with hyperglycemic and was a risk factor of infection and tumor occurrence |
| title_fullStr | Increased monocytic myeloid-derived suppressor cells in type 2 diabetes correlate with hyperglycemic and was a risk factor of infection and tumor occurrence |
| title_full_unstemmed | Increased monocytic myeloid-derived suppressor cells in type 2 diabetes correlate with hyperglycemic and was a risk factor of infection and tumor occurrence |
| title_short | Increased monocytic myeloid-derived suppressor cells in type 2 diabetes correlate with hyperglycemic and was a risk factor of infection and tumor occurrence |
| title_sort | increased monocytic myeloid derived suppressor cells in type 2 diabetes correlate with hyperglycemic and was a risk factor of infection and tumor occurrence |
| url | https://doi.org/10.1038/s41598-024-54496-w |
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