A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin
Biosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a type III polyketide synthase (PKS) using one p-coumaroyl-CoA and three malonyl-CoA molecules as substrates. Here, the authors report a fungal non-ribosomal peptide synthetase PKS hybrid FnsA catalysing the for...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34150-7 |
| _version_ | 1811192363508301824 |
|---|---|
| author | Hongjiao Zhang Zixin Li Shuang Zhou Shu-Ming Li Huomiao Ran Zili Song Tao Yu Wen-Bing Yin |
| author_facet | Hongjiao Zhang Zixin Li Shuang Zhou Shu-Ming Li Huomiao Ran Zili Song Tao Yu Wen-Bing Yin |
| author_sort | Hongjiao Zhang |
| collection | DOAJ |
| description | Biosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a type III polyketide synthase (PKS) using one p-coumaroyl-CoA and three malonyl-CoA molecules as substrates. Here, the authors report a fungal non-ribosomal peptide synthetase PKS hybrid FnsA catalysing the formation of naringenin. |
| first_indexed | 2024-04-11T23:52:31Z |
| format | Article |
| id | doaj.art-f82d5748e22c4ccdbc96f44f4f4c9bfb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T23:52:31Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f82d5748e22c4ccdbc96f44f4f4c9bfb2022-12-22T03:56:28ZengNature PortfolioNature Communications2041-17232022-10-0113111110.1038/s41467-022-34150-7A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringeninHongjiao Zhang0Zixin Li1Shuang Zhou2Shu-Ming Li3Huomiao Ran4Zili Song5Tao Yu6Wen-Bing Yin7State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of SciencesState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of SciencesState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of SciencesInstitut für Pharmazeutische Biologie und Biotechnologie, Fachbereich Pharmazie, Philipps-Universität MarburgState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of SciencesState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of SciencesCenter for Synthetic Biochemistry, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes for Advanced Technology, Chinese Academy of SciencesState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of SciencesBiosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a type III polyketide synthase (PKS) using one p-coumaroyl-CoA and three malonyl-CoA molecules as substrates. Here, the authors report a fungal non-ribosomal peptide synthetase PKS hybrid FnsA catalysing the formation of naringenin.https://doi.org/10.1038/s41467-022-34150-7 |
| spellingShingle | Hongjiao Zhang Zixin Li Shuang Zhou Shu-Ming Li Huomiao Ran Zili Song Tao Yu Wen-Bing Yin A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin Nature Communications |
| title | A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin |
| title_full | A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin |
| title_fullStr | A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin |
| title_full_unstemmed | A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin |
| title_short | A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin |
| title_sort | fungal nrps pks enzyme catalyses the formation of the flavonoid naringenin |
| url | https://doi.org/10.1038/s41467-022-34150-7 |
| work_keys_str_mv | AT hongjiaozhang afungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT zixinli afungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT shuangzhou afungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT shumingli afungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT huomiaoran afungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT zilisong afungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT taoyu afungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT wenbingyin afungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT hongjiaozhang fungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT zixinli fungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT shuangzhou fungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT shumingli fungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT huomiaoran fungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT zilisong fungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT taoyu fungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin AT wenbingyin fungalnrpspksenzymecatalysestheformationoftheflavonoidnaringenin |