The origin and spread of CRF85_BC, driven by heterosexual transmission among older people in Sichuan, China
Abstract Background CRF_BC recombinants, including CRF07_BC and CRF08_BC, were considered the predominant subtypes in China. Since the discovery of HIV-1 circulating recombinant form CRF 85_BC in Southwest China in 2016, this BC recombinant forms had been reported in different regions of China. Howe...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05488-4 |
| _version_ | 1818255044424761344 |
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| author | Ling Su Yi Feng Shu Liang Yali Zeng Yiping Li Hong Yang Li Ye Qiushi Wang Dongbin Wei Dan Yuan Wenhong Lai Linglin Zhang |
| author_facet | Ling Su Yi Feng Shu Liang Yali Zeng Yiping Li Hong Yang Li Ye Qiushi Wang Dongbin Wei Dan Yuan Wenhong Lai Linglin Zhang |
| author_sort | Ling Su |
| collection | DOAJ |
| description | Abstract Background CRF_BC recombinants, including CRF07_BC and CRF08_BC, were considered the predominant subtypes in China. Since the discovery of HIV-1 circulating recombinant form CRF 85_BC in Southwest China in 2016, this BC recombinant forms had been reported in different regions of China. However, the history and magnitude of CRF85_BC transmission were still to be investigated. Method We conducted the most recent molecular epidemiology of HIV-1 among newly reported HIV-1 infected patients in Sichuan in 2019 by sequencing and phylogenetic analysis of 1291 pol sequences. Then, we used maximum likelihood approach and the Bayesian Markov chain Monte Carlo (MCMC) sampling of pol sequences to reconstruct the phylogeographic and demographic dynamics of the CRF85_BC. Results HIV-1 CRF85_BC (68/1291, 5.27%) became the fourth most prevalent strain revealing a significant increase in local population. CRF85_BC were only found in heterosexually infected individuals and the majority of CRF85_BC (95.45%) were circulating among the people living with HIV aged 50 years and over (PLHIV50+), suggesting a unique prevalent pattern. The founder lineages of CRF85_BC were likely to have first emerged in Yunnan, a province of Southwest China bordering Sichuan, in the early 2000s. It then spread exponentially to various places (including Guangxi, Sichuan, et al) and became endemic around 2008.6 (2006.7–2010.2) in Sichuan. Conclusion Taken together, our findings on HIV-1 subtype CRF85_BC infections provided new insights into the spread of this virus and extended the understanding of the HIV epidemic in China. |
| first_indexed | 2024-12-12T17:05:36Z |
| format | Article |
| id | doaj.art-f82e9a1b13f9448da2b55757cba7e5b8 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T17:05:36Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-f82e9a1b13f9448da2b55757cba7e5b82022-12-22T00:18:01ZengBMCBMC Infectious Diseases1471-23342020-10-012011810.1186/s12879-020-05488-4The origin and spread of CRF85_BC, driven by heterosexual transmission among older people in Sichuan, ChinaLing Su0Yi Feng1Shu Liang2Yali Zeng3Yiping Li4Hong Yang5Li Ye6Qiushi Wang7Dongbin Wei8Dan Yuan9Wenhong Lai10Linglin Zhang11Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionDivision of Virology and Immunology, National Center for AIDS/STD Control and Prevention (NCAIDS), China CDCSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and PreventionAbstract Background CRF_BC recombinants, including CRF07_BC and CRF08_BC, were considered the predominant subtypes in China. Since the discovery of HIV-1 circulating recombinant form CRF 85_BC in Southwest China in 2016, this BC recombinant forms had been reported in different regions of China. However, the history and magnitude of CRF85_BC transmission were still to be investigated. Method We conducted the most recent molecular epidemiology of HIV-1 among newly reported HIV-1 infected patients in Sichuan in 2019 by sequencing and phylogenetic analysis of 1291 pol sequences. Then, we used maximum likelihood approach and the Bayesian Markov chain Monte Carlo (MCMC) sampling of pol sequences to reconstruct the phylogeographic and demographic dynamics of the CRF85_BC. Results HIV-1 CRF85_BC (68/1291, 5.27%) became the fourth most prevalent strain revealing a significant increase in local population. CRF85_BC were only found in heterosexually infected individuals and the majority of CRF85_BC (95.45%) were circulating among the people living with HIV aged 50 years and over (PLHIV50+), suggesting a unique prevalent pattern. The founder lineages of CRF85_BC were likely to have first emerged in Yunnan, a province of Southwest China bordering Sichuan, in the early 2000s. It then spread exponentially to various places (including Guangxi, Sichuan, et al) and became endemic around 2008.6 (2006.7–2010.2) in Sichuan. Conclusion Taken together, our findings on HIV-1 subtype CRF85_BC infections provided new insights into the spread of this virus and extended the understanding of the HIV epidemic in China.http://link.springer.com/article/10.1186/s12879-020-05488-4HIV-1RecombinantsHeterosexually transmission |
| spellingShingle | Ling Su Yi Feng Shu Liang Yali Zeng Yiping Li Hong Yang Li Ye Qiushi Wang Dongbin Wei Dan Yuan Wenhong Lai Linglin Zhang The origin and spread of CRF85_BC, driven by heterosexual transmission among older people in Sichuan, China BMC Infectious Diseases HIV-1 Recombinants Heterosexually transmission |
| title | The origin and spread of CRF85_BC, driven by heterosexual transmission among older people in Sichuan, China |
| title_full | The origin and spread of CRF85_BC, driven by heterosexual transmission among older people in Sichuan, China |
| title_fullStr | The origin and spread of CRF85_BC, driven by heterosexual transmission among older people in Sichuan, China |
| title_full_unstemmed | The origin and spread of CRF85_BC, driven by heterosexual transmission among older people in Sichuan, China |
| title_short | The origin and spread of CRF85_BC, driven by heterosexual transmission among older people in Sichuan, China |
| title_sort | origin and spread of crf85 bc driven by heterosexual transmission among older people in sichuan china |
| topic | HIV-1 Recombinants Heterosexually transmission |
| url | http://link.springer.com/article/10.1186/s12879-020-05488-4 |
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