Efficacious and safe control of glycemia using Apidra insulin
Diabetes mellitus (DM) is a stably growing pathology leading to micro- and macrovascular complications. Despite high potential of medicamentaltherapy for DM its efficacy needs to be further improved. Uncompensated postprandial hyperglycemia is known to be responsible for many diabeticcomplications....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2010-09-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5492 |
| _version_ | 1797255319351459840 |
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| author | Elena Valer'evna Biryukova Maria Alexandrovna Garbuzova |
| author_facet | Elena Valer'evna Biryukova Maria Alexandrovna Garbuzova |
| author_sort | Elena Valer'evna Biryukova |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a stably growing pathology leading to micro- and macrovascular complications. Despite high potential of medicamentaltherapy for DM its efficacy needs to be further improved. Uncompensated postprandial hyperglycemia is known to be responsible for many diabeticcomplications. Moreover, it by itself aggravates disturbances of insulin secretion through the toxic effect of glucose. Insulin therapy remains a principaltool for the treatment of DM. Its efficiency was greatly improved with the advent of fast-acting insulin analogs obtained by reducing stability of hexamers.Insulin glulysine (Apidra) is the fastest-acting analog licensed for the treatment of DM1 and DM2 in adult patients in 2004 (FDA, EMEA) andin children above 6 years in 2008 (EMEA). A characteristic feature of this analog is the absence of Zn2+ in its molecule that substitutes polysorbate-20 acting as a surfactant and providing additional protection of monomers from denaturation. |
| first_indexed | 2024-03-08T15:22:55Z |
| format | Article |
| id | doaj.art-f82f368724944cdb8da4a2a61c74cc87 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:03:58Z |
| publishDate | 2010-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-f82f368724944cdb8da4a2a61c74cc872024-03-20T11:47:56ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782010-09-01133727710.14341/2072-0351-54925450Efficacious and safe control of glycemia using Apidra insulinElena Valer'evna Biryukova0Maria Alexandrovna Garbuzova1ГОУ ВПО Московский государственный медико-стоматологический университет, МоскваГОУ ВПО Московский государственный медико-стоматологический университет, МоскваDiabetes mellitus (DM) is a stably growing pathology leading to micro- and macrovascular complications. Despite high potential of medicamentaltherapy for DM its efficacy needs to be further improved. Uncompensated postprandial hyperglycemia is known to be responsible for many diabeticcomplications. Moreover, it by itself aggravates disturbances of insulin secretion through the toxic effect of glucose. Insulin therapy remains a principaltool for the treatment of DM. Its efficiency was greatly improved with the advent of fast-acting insulin analogs obtained by reducing stability of hexamers.Insulin glulysine (Apidra) is the fastest-acting analog licensed for the treatment of DM1 and DM2 in adult patients in 2004 (FDA, EMEA) andin children above 6 years in 2008 (EMEA). A characteristic feature of this analog is the absence of Zn2+ in its molecule that substitutes polysorbate-20 acting as a surfactant and providing additional protection of monomers from denaturation.https://www.dia-endojournals.ru/jour/article/view/5492diabetes mellitushyperglycemiacomplicationstreatmentapidraglulysine |
| spellingShingle | Elena Valer'evna Biryukova Maria Alexandrovna Garbuzova Efficacious and safe control of glycemia using Apidra insulin Сахарный диабет diabetes mellitus hyperglycemia complications treatment apidra glulysine |
| title | Efficacious and safe control of glycemia using Apidra insulin |
| title_full | Efficacious and safe control of glycemia using Apidra insulin |
| title_fullStr | Efficacious and safe control of glycemia using Apidra insulin |
| title_full_unstemmed | Efficacious and safe control of glycemia using Apidra insulin |
| title_short | Efficacious and safe control of glycemia using Apidra insulin |
| title_sort | efficacious and safe control of glycemia using apidra insulin |
| topic | diabetes mellitus hyperglycemia complications treatment apidra glulysine |
| url | https://www.dia-endojournals.ru/jour/article/view/5492 |
| work_keys_str_mv | AT elenavalerevnabiryukova efficaciousandsafecontrolofglycemiausingapidrainsulin AT mariaalexandrovnagarbuzova efficaciousandsafecontrolofglycemiausingapidrainsulin |