| Summary: | Objectives: General population studies have shown associations between Copy Number Variation (CNV) of the LPA gene Kringle-IV type-2 (KIV-2) coding region, single nucleotide polymorphism (SNP) rs6415084 in LPA and coronary heart disease (CHD). Because risk factors for HIV-infected patients may differ from the general population, we aimed to assess whether these potential associations also occur in HIV-infected patients.Methods: A unicenter, retrospective, case-control (1:3) study. 18 HIV-patients with confirmed diagnosis of acute myocardial infarction (AMI) were adjusted for age, gender and time since HIV diagnosis to 54 HIV-patients without CHD. After gDNA extraction from frozen blood, both CNV and SNP genotyping were performed using real time quantitative PCR. All genetic and non-genetic variables for AMI were assessed in a logistic regression analysis.Results: Our results did not confirm any association in terms of lipoprotein (a) LPA structural genetic variants when comparing KIV-2 CNV (p=0.67) and SNP genotypes (p=0.44) between AMI cases and controls. However, traditional risk factors such as diabetes mellitus, hypertension, and CD4+ T-cell count showed association (p<0.05) with CHD.Conclusions: Although significant associations of AMI with diabetes, hypertension and CD4+ T-cell count in HIV-patients were found, this study could not confirm the feasibility neither of KIV-2 CNV nor rs6415084 in LPA as genetic markers of CHD in HIV-infected patients.
|
|---|