Original Antigenic Sin and Respiratory Syncytial Virus Vaccines
The original antigenic sin (OAS) theory considers the outcome of the first encounter with an antigen. It favors a memory response to the original antigen upon exposure to a similar or related antigen, and includes both positive and negative impacts of past exposure on the memory response to challeng...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/7/3/107 |
| _version_ | 1818013124132864000 |
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| author | Ralph A. Tripp Ultan F. Power |
| author_facet | Ralph A. Tripp Ultan F. Power |
| author_sort | Ralph A. Tripp |
| collection | DOAJ |
| description | The original antigenic sin (OAS) theory considers the outcome of the first encounter with an antigen. It favors a memory response to the original antigen upon exposure to a similar or related antigen, and includes both positive and negative impacts of past exposure on the memory response to challenge, and, in particular, on vaccine efficacy. This phenomenon is closely linked with imprinting and the hierarchical nature of immune responses to previously encountered antigens. The focus of this commentary centers on the potential role of OAS or immunological imprinting on respiratory syncytial virus memory responses. |
| first_indexed | 2024-04-14T06:28:28Z |
| format | Article |
| id | doaj.art-f836959bdf0d41679cdd2bf158ff5e40 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-14T06:28:28Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-f836959bdf0d41679cdd2bf158ff5e402022-12-22T02:07:42ZengMDPI AGVaccines2076-393X2019-09-017310710.3390/vaccines7030107vaccines7030107Original Antigenic Sin and Respiratory Syncytial Virus VaccinesRalph A. Tripp0Ultan F. Power1Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USAWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast BT9 7BL, Northern IrelandThe original antigenic sin (OAS) theory considers the outcome of the first encounter with an antigen. It favors a memory response to the original antigen upon exposure to a similar or related antigen, and includes both positive and negative impacts of past exposure on the memory response to challenge, and, in particular, on vaccine efficacy. This phenomenon is closely linked with imprinting and the hierarchical nature of immune responses to previously encountered antigens. The focus of this commentary centers on the potential role of OAS or immunological imprinting on respiratory syncytial virus memory responses.https://www.mdpi.com/2076-393X/7/3/107original antigenic sinOASRSVvaccinesvaccine effectivenessVEimmunological memory |
| spellingShingle | Ralph A. Tripp Ultan F. Power Original Antigenic Sin and Respiratory Syncytial Virus Vaccines Vaccines original antigenic sin OAS RSV vaccines vaccine effectiveness VE immunological memory |
| title | Original Antigenic Sin and Respiratory Syncytial Virus Vaccines |
| title_full | Original Antigenic Sin and Respiratory Syncytial Virus Vaccines |
| title_fullStr | Original Antigenic Sin and Respiratory Syncytial Virus Vaccines |
| title_full_unstemmed | Original Antigenic Sin and Respiratory Syncytial Virus Vaccines |
| title_short | Original Antigenic Sin and Respiratory Syncytial Virus Vaccines |
| title_sort | original antigenic sin and respiratory syncytial virus vaccines |
| topic | original antigenic sin OAS RSV vaccines vaccine effectiveness VE immunological memory |
| url | https://www.mdpi.com/2076-393X/7/3/107 |
| work_keys_str_mv | AT ralphatripp originalantigenicsinandrespiratorysyncytialvirusvaccines AT ultanfpower originalantigenicsinandrespiratorysyncytialvirusvaccines |