Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange

Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange

Actin assembly is important for cell motility. The ability of actin subunits to join or leave filaments via the barbed end is critical to actin dynamics. Capping protein (CP) binds to barbed ends to prevent subunit gain and loss and is regulated by proteins that include V-1 and CARMIL. V-1 inhibits...

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Bibliographic Details
Main Authors: Britney Johnson, Patrick McConnell, Alex G. Kozlov, Marlene Mekel, Timothy M. Lohman, Michael L. Gross, Gaya K. Amarasinghe, John A. Cooper
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
allostery
actin regulation
CARMIL
hydrogen-deuterium exchange
mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718306740

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