Glucose-6-phosphate dehydrogenase (G6PD) Deficiency
"nGlucose-6-phosphate dehydrogenase (G6PD) Deficiency is the most prevalent enzymopathy in mankind. It has sex-linked in­heritance. This enzyme exists in all cells.  G6PD deficiency increases the sensitivity of red blood cells to oxidative dam­age. G6PD...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2008-12-01
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| Series: | Iranian Journal of Public Health |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/12366.pdf&manuscript_id=12366 |
| _version_ | 1819168243867189248 |
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| author | DD Farhud L Yazdanpanah |
| author_facet | DD Farhud L Yazdanpanah |
| author_sort | DD Farhud |
| collection | DOAJ |
| description | "nGlucose-6-phosphate dehydrogenase (G6PD) Deficiency is the most prevalent enzymopathy in mankind. It has sex-linked in­heritance. This enzyme exists in all cells.  G6PD deficiency increases the sensitivity of red blood cells to oxidative dam­age. G6PD deficiency was discovered in 1950 when some people suffered hemolytic anemia as a result of taking antimalar­ial drugs (primaquin). Most people with G6PD deficiency do not have any symptoms, till they are exposed to certain medi­cations, Fava beans and infections; and then their red blood cells are hemolyzed. The degree of hemolysis changes accord­ing to the degree of enzyme deficiency and the oxidant agent exposure. G6PD deficiency has many different variants and Medi­terranean variant is the most common mutation in the world. G6PD deficiency is considered a health problem world­wide, especially in Asia, Middle East and Mediterranean countries. In this article, we have reviewed the importance and func­tion of G6PD enzyme, incidence rate of G6PD deficiency in the world and Iran, genetic and variants of this enzyme, clini­cal manifestation, diagnosis and treatment of the enzyme deficiency. |
| first_indexed | 2024-12-22T19:00:31Z |
| format | Article |
| id | doaj.art-f83bc3342721438891a6b9b919e6e28b |
| institution | Directory Open Access Journal |
| issn | 2251-6085 |
| language | English |
| last_indexed | 2024-12-22T19:00:31Z |
| publishDate | 2008-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-f83bc3342721438891a6b9b919e6e28b2022-12-21T18:15:57ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852008-12-01374118Glucose-6-phosphate dehydrogenase (G6PD) DeficiencyDD FarhudL Yazdanpanah"nGlucose-6-phosphate dehydrogenase (G6PD) Deficiency is the most prevalent enzymopathy in mankind. It has sex-linked in­heritance. This enzyme exists in all cells.  G6PD deficiency increases the sensitivity of red blood cells to oxidative dam­age. G6PD deficiency was discovered in 1950 when some people suffered hemolytic anemia as a result of taking antimalar­ial drugs (primaquin). Most people with G6PD deficiency do not have any symptoms, till they are exposed to certain medi­cations, Fava beans and infections; and then their red blood cells are hemolyzed. The degree of hemolysis changes accord­ing to the degree of enzyme deficiency and the oxidant agent exposure. G6PD deficiency has many different variants and Medi­terranean variant is the most common mutation in the world. G6PD deficiency is considered a health problem world­wide, especially in Asia, Middle East and Mediterranean countries. In this article, we have reviewed the importance and func­tion of G6PD enzyme, incidence rate of G6PD deficiency in the world and Iran, genetic and variants of this enzyme, clini­cal manifestation, diagnosis and treatment of the enzyme deficiency.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/12366.pdf&manuscript_id=12366G6PDOxidative damageSex-linked inheritanceHemolytic anemiaMediterranean variant |
| spellingShingle | DD Farhud L Yazdanpanah Glucose-6-phosphate dehydrogenase (G6PD) Deficiency Iranian Journal of Public Health G6PD Oxidative damage Sex-linked inheritance Hemolytic anemia Mediterranean variant |
| title | Glucose-6-phosphate dehydrogenase (G6PD) Deficiency |
| title_full | Glucose-6-phosphate dehydrogenase (G6PD) Deficiency |
| title_fullStr | Glucose-6-phosphate dehydrogenase (G6PD) Deficiency |
| title_full_unstemmed | Glucose-6-phosphate dehydrogenase (G6PD) Deficiency |
| title_short | Glucose-6-phosphate dehydrogenase (G6PD) Deficiency |
| title_sort | glucose 6 phosphate dehydrogenase g6pd deficiency |
| topic | G6PD Oxidative damage Sex-linked inheritance Hemolytic anemia Mediterranean variant |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/12366.pdf&manuscript_id=12366 |
| work_keys_str_mv | AT ddfarhud glucose6phosphatedehydrogenaseg6pddeficiency AT lyazdanpanah glucose6phosphatedehydrogenaseg6pddeficiency |