Effects of a Two-Month Exercise Training Program on Concurrent Non-Opiate Substance Use in Opioid-Dependent Patients during Substitution Treatment
Background: This randomized controlled trial aimed to evaluate the effects of a two-month exercise intervention on the concurrent non-opiate substance use (alcohol, cocaine, cannabis, and benzodiazepines) in opioid users during their medication treatment. Methods: Ninety opioid users (41 females) in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/4/941 |
| _version_ | 1797297912238047232 |
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| author | Alexandros Psarianos Costas Chryssanthopoulos Athanasios Theocharis Thomas Paparrigopoulos Anastassios Philippou |
| author_facet | Alexandros Psarianos Costas Chryssanthopoulos Athanasios Theocharis Thomas Paparrigopoulos Anastassios Philippou |
| author_sort | Alexandros Psarianos |
| collection | DOAJ |
| description | Background: This randomized controlled trial aimed to evaluate the effects of a two-month exercise intervention on the concurrent non-opiate substance use (alcohol, cocaine, cannabis, and benzodiazepines) in opioid users during their medication treatment. Methods: Ninety opioid users (41 females) in methadone and buprenorphine medication treatment were randomly divided into four groups: (a) buprenorphine experimental (BEX; n = 26, aged 41.9 ± 6.1 yrs); (b) buprenorphine control (BCON; n = 25, aged 41.9 ± 5.6 yrs); (c) methadone experimental (MEX; n = 20, aged 46.7 ± 6.6 yrs); and (d) methadone control (MCON; n = 19, aged 46.1 ± 7.5 yrs). The experimental groups (BEX and MEX) followed an aerobic exercise training program on a treadmill for 20 min at 70% HR<sub>max</sub>, 3 days/week for 8 weeks. Socio-demographic, anthropometric, and clinical characteristics, as well as non-opioid drug use in days and quantity per week, were assessed before and after the intervention period. Results: Following the exercise training, the weekly non-opioid substance consumption (days) decreased (<i>p</i> < 0.05) in both exercise groups and was lower in BEX compared to MEX, while no differences were observed (<i>p</i> > 0.05) between the control groups (BCON vs. MCON) or compared to their baseline levels. Similarly, the daily amount of non-opiate substance intake was reduced (<i>p</i> < 0.05) post-training in BEX and MEX, whereas it did not differ (<i>p</i> > 0.05) in BCON and MCON compared to the baseline. Conclusions: The two-month exercise intervention reduced the non-opioid drug use in both the methadone and buprenorphine substitution groups compared to the controls, suggesting that aerobic exercise training may be an effective strategy for treating patients with OUDs. |
| first_indexed | 2024-03-07T22:28:11Z |
| format | Article |
| id | doaj.art-f83cb0f71c8b4e46af9bf4d74bb54929 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-07T22:28:11Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f83cb0f71c8b4e46af9bf4d74bb549292024-02-23T15:21:50ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-0113494110.3390/jcm13040941Effects of a Two-Month Exercise Training Program on Concurrent Non-Opiate Substance Use in Opioid-Dependent Patients during Substitution TreatmentAlexandros Psarianos0Costas Chryssanthopoulos1Athanasios Theocharis2Thomas Paparrigopoulos3Anastassios Philippou41st Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, 11528 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceGreek Organization Against Drugs (OΚAΝA), 10433 Athens, Greece1st Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, 11528 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceBackground: This randomized controlled trial aimed to evaluate the effects of a two-month exercise intervention on the concurrent non-opiate substance use (alcohol, cocaine, cannabis, and benzodiazepines) in opioid users during their medication treatment. Methods: Ninety opioid users (41 females) in methadone and buprenorphine medication treatment were randomly divided into four groups: (a) buprenorphine experimental (BEX; n = 26, aged 41.9 ± 6.1 yrs); (b) buprenorphine control (BCON; n = 25, aged 41.9 ± 5.6 yrs); (c) methadone experimental (MEX; n = 20, aged 46.7 ± 6.6 yrs); and (d) methadone control (MCON; n = 19, aged 46.1 ± 7.5 yrs). The experimental groups (BEX and MEX) followed an aerobic exercise training program on a treadmill for 20 min at 70% HR<sub>max</sub>, 3 days/week for 8 weeks. Socio-demographic, anthropometric, and clinical characteristics, as well as non-opioid drug use in days and quantity per week, were assessed before and after the intervention period. Results: Following the exercise training, the weekly non-opioid substance consumption (days) decreased (<i>p</i> < 0.05) in both exercise groups and was lower in BEX compared to MEX, while no differences were observed (<i>p</i> > 0.05) between the control groups (BCON vs. MCON) or compared to their baseline levels. Similarly, the daily amount of non-opiate substance intake was reduced (<i>p</i> < 0.05) post-training in BEX and MEX, whereas it did not differ (<i>p</i> > 0.05) in BCON and MCON compared to the baseline. Conclusions: The two-month exercise intervention reduced the non-opioid drug use in both the methadone and buprenorphine substitution groups compared to the controls, suggesting that aerobic exercise training may be an effective strategy for treating patients with OUDs.https://www.mdpi.com/2077-0383/13/4/941aerobic exerciseexercise trainingnon-opiate substance abuseconcurrent useopioid usersmedication for opioid use disorders |
| spellingShingle | Alexandros Psarianos Costas Chryssanthopoulos Athanasios Theocharis Thomas Paparrigopoulos Anastassios Philippou Effects of a Two-Month Exercise Training Program on Concurrent Non-Opiate Substance Use in Opioid-Dependent Patients during Substitution Treatment Journal of Clinical Medicine aerobic exercise exercise training non-opiate substance abuse concurrent use opioid users medication for opioid use disorders |
| title | Effects of a Two-Month Exercise Training Program on Concurrent Non-Opiate Substance Use in Opioid-Dependent Patients during Substitution Treatment |
| title_full | Effects of a Two-Month Exercise Training Program on Concurrent Non-Opiate Substance Use in Opioid-Dependent Patients during Substitution Treatment |
| title_fullStr | Effects of a Two-Month Exercise Training Program on Concurrent Non-Opiate Substance Use in Opioid-Dependent Patients during Substitution Treatment |
| title_full_unstemmed | Effects of a Two-Month Exercise Training Program on Concurrent Non-Opiate Substance Use in Opioid-Dependent Patients during Substitution Treatment |
| title_short | Effects of a Two-Month Exercise Training Program on Concurrent Non-Opiate Substance Use in Opioid-Dependent Patients during Substitution Treatment |
| title_sort | effects of a two month exercise training program on concurrent non opiate substance use in opioid dependent patients during substitution treatment |
| topic | aerobic exercise exercise training non-opiate substance abuse concurrent use opioid users medication for opioid use disorders |
| url | https://www.mdpi.com/2077-0383/13/4/941 |
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