Safety Evaluation and Anti-Inflammatory Efficacy of <i>Lacticaseibacillus paracasei</i> PS23
<i>Lacticaseibacillus paracasei</i> strain PS23 (PS23) exhibits some probiotic properties. In this study, a genomic analysis of PS23 revealed no genes related to virulence or antibiotic resistance. Moreover, ornithine decarboxylase activity was not detected in vitro. In addition, PS23 wa...
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MDPI AG
2022-12-01
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Online Access: | https://www.mdpi.com/1422-0067/24/1/724 |
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author | Chin-Hao Li Tai-Ying Chen Chien-Chen Wu Shih-Hsuan Cheng Min-Yu Chang Wei-Hong Cheng Shih-Hau Chiu Chien-Chi Chen Ying-Chieh Tsai Deng-Jye Yang Jaw-Jou Kang Po-Lin Liao |
author_facet | Chin-Hao Li Tai-Ying Chen Chien-Chen Wu Shih-Hsuan Cheng Min-Yu Chang Wei-Hong Cheng Shih-Hau Chiu Chien-Chi Chen Ying-Chieh Tsai Deng-Jye Yang Jaw-Jou Kang Po-Lin Liao |
author_sort | Chin-Hao Li |
collection | DOAJ |
description | <i>Lacticaseibacillus paracasei</i> strain PS23 (PS23) exhibits some probiotic properties. In this study, a genomic analysis of PS23 revealed no genes related to virulence or antibiotic resistance. Moreover, ornithine decarboxylase activity was not detected in vitro. In addition, PS23 was sensitive to the tested antibiotics. Genotoxicity tests for PS23 including the Ames test and chromosomal aberrations in vitro using Chinese hamster ovary cells and micronuclei in immature erythrocytes of ICR mice were all negative. Moreover, following a 28-day study involving repeated oral dose toxicity tests (40, 400, and 4000 mg/kg equal 1.28 × 10<sup>10</sup>, 1.28 × 10<sup>11</sup>, and 1.28 × 10<sup>12</sup> CFU/kg body weight, respectively) using an ICR mouse model, no adverse effects were observed from any doses. In addition, supplementation with live or heat-killed PS23 ameliorates DSS-induced colonic inflammation in mice. Our findings suggest that PS23 is safe and has anti-inflammatory effects and may therefore have therapeutic implications. |
first_indexed | 2024-03-11T09:58:26Z |
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institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-11T09:58:26Z |
publishDate | 2022-12-01 |
publisher | MDPI AG |
record_format | Article |
series | International Journal of Molecular Sciences |
spelling | doaj.art-f83ccd3f96d44c78b9d6b6d337b219622023-11-16T15:37:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124172410.3390/ijms24010724Safety Evaluation and Anti-Inflammatory Efficacy of <i>Lacticaseibacillus paracasei</i> PS23Chin-Hao Li0Tai-Ying Chen1Chien-Chen Wu2Shih-Hsuan Cheng3Min-Yu Chang4Wei-Hong Cheng5Shih-Hau Chiu6Chien-Chi Chen7Ying-Chieh Tsai8Deng-Jye Yang9Jaw-Jou Kang10Po-Lin Liao11Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, TaiwanGraduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, TaiwanBened Biomedical Co., Ltd., Taipei 104, TaiwanInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, TaiwanInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, TaiwanInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, TaiwanBioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu 300, TaiwanBioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu 300, TaiwanBened Biomedical Co., Ltd., Taipei 104, TaiwanInstitute of Food Safety and Health Risk Assessment, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, TaiwanInstitute of Food Safety and Health Risk Assessment, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, TaiwanInstitute of Food Safety and Health Risk Assessment, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan<i>Lacticaseibacillus paracasei</i> strain PS23 (PS23) exhibits some probiotic properties. In this study, a genomic analysis of PS23 revealed no genes related to virulence or antibiotic resistance. Moreover, ornithine decarboxylase activity was not detected in vitro. In addition, PS23 was sensitive to the tested antibiotics. Genotoxicity tests for PS23 including the Ames test and chromosomal aberrations in vitro using Chinese hamster ovary cells and micronuclei in immature erythrocytes of ICR mice were all negative. Moreover, following a 28-day study involving repeated oral dose toxicity tests (40, 400, and 4000 mg/kg equal 1.28 × 10<sup>10</sup>, 1.28 × 10<sup>11</sup>, and 1.28 × 10<sup>12</sup> CFU/kg body weight, respectively) using an ICR mouse model, no adverse effects were observed from any doses. In addition, supplementation with live or heat-killed PS23 ameliorates DSS-induced colonic inflammation in mice. Our findings suggest that PS23 is safe and has anti-inflammatory effects and may therefore have therapeutic implications.https://www.mdpi.com/1422-0067/24/1/724<i>Lacticaseibacillus paracasei</i> PS23genome-based safety assessment28-day repeated oral dose toxicitygenotoxicity testno observed adverse effect level |
spellingShingle | Chin-Hao Li Tai-Ying Chen Chien-Chen Wu Shih-Hsuan Cheng Min-Yu Chang Wei-Hong Cheng Shih-Hau Chiu Chien-Chi Chen Ying-Chieh Tsai Deng-Jye Yang Jaw-Jou Kang Po-Lin Liao Safety Evaluation and Anti-Inflammatory Efficacy of <i>Lacticaseibacillus paracasei</i> PS23 International Journal of Molecular Sciences <i>Lacticaseibacillus paracasei</i> PS23 genome-based safety assessment 28-day repeated oral dose toxicity genotoxicity test no observed adverse effect level |
title | Safety Evaluation and Anti-Inflammatory Efficacy of <i>Lacticaseibacillus paracasei</i> PS23 |
title_full | Safety Evaluation and Anti-Inflammatory Efficacy of <i>Lacticaseibacillus paracasei</i> PS23 |
title_fullStr | Safety Evaluation and Anti-Inflammatory Efficacy of <i>Lacticaseibacillus paracasei</i> PS23 |
title_full_unstemmed | Safety Evaluation and Anti-Inflammatory Efficacy of <i>Lacticaseibacillus paracasei</i> PS23 |
title_short | Safety Evaluation and Anti-Inflammatory Efficacy of <i>Lacticaseibacillus paracasei</i> PS23 |
title_sort | safety evaluation and anti inflammatory efficacy of i lacticaseibacillus paracasei i ps23 |
topic | <i>Lacticaseibacillus paracasei</i> PS23 genome-based safety assessment 28-day repeated oral dose toxicity genotoxicity test no observed adverse effect level |
url | https://www.mdpi.com/1422-0067/24/1/724 |
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