Deep learning for de-convolution of Smad2 versus Smad3 binding sites

Deep learning for de-convolution of Smad2 versus Smad3 binding sites

Abstract Background The transforming growth factor beta-1 (TGF β-1) cytokine exerts both pro-tumor and anti-tumor effects in carcinogenesis. An increasing body of literature suggests that TGF β-1 signaling outcome is partially dependent on the regulatory targets of downstream receptor-regulated Smad...

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Bibliographic Details
Main Authors: Jeremy W.K. Ng, Esther H.Q. Ong, Lisa Tucker-Kellogg, Greg Tucker-Kellogg
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Genomics
Subjects:
Machine learning
Transcription regulation
Feature engineering
Online Access:https://doi.org/10.1186/s12864-022-08565-x

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