A refined, rapid and reproducible high resolution melt (HRM)-based method suitable for quantification of global LINE-1 repetitive element methylation

A refined, rapid and reproducible high resolution melt (HRM)-based method suitable for quantification of global LINE-1 repetitive element methylation

<p>Abstract</p> <p>Background</p> <p>The methylation of DNA is recognized as a key mechanism in the regulation of genomic stability and evidence for its role in the development of cancer is accumulating. LINE-1 methylation status represents a surrogate measure of genome...

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Bibliographic Details
Main Authors: Tse M Yat, Ashbury Janet E, Zwingerman Nora, King Will D, Taylor Sherry AM, Pang Stephen C
Format: Article
Language:English
Published: BMC 2011-12-01
Series:BMC Research Notes
Online Access:http://www.biomedcentral.com/1756-0500/4/565

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