Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and Applications
A dog is a valuable animal model and concomitantly a pet for which advanced therapies are increasingly in demand. The characteristics of mesenchymal stem/stromal cells (MSCs) have made cell therapy more clinically attractive. During the last decade, research on the MSC therapeutic effectiveness has...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/22/3571 |
| _version_ | 1827640899402727424 |
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| author | Barbara Merlo Eleonora Iacono |
| author_facet | Barbara Merlo Eleonora Iacono |
| author_sort | Barbara Merlo |
| collection | DOAJ |
| description | A dog is a valuable animal model and concomitantly a pet for which advanced therapies are increasingly in demand. The characteristics of mesenchymal stem/stromal cells (MSCs) have made cell therapy more clinically attractive. During the last decade, research on the MSC therapeutic effectiveness has demonstrated that tissue regeneration is primarily mediated by paracrine factors, which are included under the name of secretome. Secretome is a mixture of soluble factors and a variety of extracellular vesicles. The use of secretome for therapeutic purposes could have some advantages compared to cell-based therapies, such as lower immunogenicity and easy manufacturing, manipulation, and storage. The conditioned medium and extracellular vesicles derived from MSCs have the potential to be employed as new treatments in veterinary medicine. This review provides an update on the state-of-the-art characterization and applications of canine adipose tissue-derived MSC secretome. |
| first_indexed | 2024-03-09T17:06:00Z |
| format | Article |
| id | doaj.art-f841a33580cf4c60933c29b2f522676a |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T17:06:00Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-f841a33580cf4c60933c29b2f522676a2023-11-24T14:25:02ZengMDPI AGAnimals2076-26152023-11-011322357110.3390/ani13223571Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and ApplicationsBarbara Merlo0Eleonora Iacono1Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, ItalyA dog is a valuable animal model and concomitantly a pet for which advanced therapies are increasingly in demand. The characteristics of mesenchymal stem/stromal cells (MSCs) have made cell therapy more clinically attractive. During the last decade, research on the MSC therapeutic effectiveness has demonstrated that tissue regeneration is primarily mediated by paracrine factors, which are included under the name of secretome. Secretome is a mixture of soluble factors and a variety of extracellular vesicles. The use of secretome for therapeutic purposes could have some advantages compared to cell-based therapies, such as lower immunogenicity and easy manufacturing, manipulation, and storage. The conditioned medium and extracellular vesicles derived from MSCs have the potential to be employed as new treatments in veterinary medicine. This review provides an update on the state-of-the-art characterization and applications of canine adipose tissue-derived MSC secretome.https://www.mdpi.com/2076-2615/13/22/3571caninemesenchymal stromal cellsadipose tissuesecretomeextracellular vesiclesconditioned medium |
| spellingShingle | Barbara Merlo Eleonora Iacono Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and Applications Animals canine mesenchymal stromal cells adipose tissue secretome extracellular vesicles conditioned medium |
| title | Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and Applications |
| title_full | Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and Applications |
| title_fullStr | Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and Applications |
| title_full_unstemmed | Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and Applications |
| title_short | Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and Applications |
| title_sort | beyond canine adipose tissue derived mesenchymal stem stromal cells transplantation an update on their secretome characterization and applications |
| topic | canine mesenchymal stromal cells adipose tissue secretome extracellular vesicles conditioned medium |
| url | https://www.mdpi.com/2076-2615/13/22/3571 |
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